Leveraging multilayered “omics” data for atopic dermatitis: a road map to precision medicine

D Ghosh, JA Bernstein, GK Khurana Hershey… - Frontiers in …, 2018 - frontiersin.org
Atopic dermatitis (AD) is a complex multifactorial inflammatory skin disease that affects~ 280
million people worldwide. About 85% of AD cases begin in childhood, a significant portion of …

Role of airway epithelial cells in the development of different asthma phenotypes

DP Potaczek, S Miethe, V Schindler, F Alhamdan… - Cellular signalling, 2020 - Elsevier
The term (bronchial) asthma describes a disorder syndrome that comprises several disease
phenotypes, all characterized by chronic inflammation in the bronchial epithelium, with a …

Iron-deficiency in atopic diseases: innate immune priming by allergens and siderophores

F Roth-Walter - Frontiers in Allergy, 2022 - frontiersin.org
Although iron is one of the most abundant elements on earth, about a third of the world's
population are affected by iron deficiency. Main drivers of iron deficiency are beside the …

Initiating pollen sensitization–complex source, complex mechanisms

L Pointner, A Bethanis, M Thaler… - Clinical and translational …, 2020 - Springer
The mechanisms involved in the induction of allergic sensitization by pollen are not fully
understood. Within the last few decades, findings from epidemiological and experimental …

Short-chain fatty acids augment differentiation and function of human induced regulatory T cells

M Hu, B Alashkar Alhamwe, B Santner-Nanan… - International Journal of …, 2022 - mdpi.com
Regulatory T cells (Tregs) control immune system activity and inhibit inflammation. While, in
mice, short-chain fatty acids (SCFAs) are known to be essential regulators of naturally …

Nasal DNA methylation at three CpG sites predicts childhood allergic disease

M van Breugel, C Qi, Z Xu, CET Pedersen… - Nature …, 2022 - nature.com
Childhood allergic diseases, including asthma, rhinitis and eczema, are prevalent conditions
that share strong genetic and environmental components. Diagnosis relies on clinical history …

Extracellular vesicles and asthma—More than just a co-existence

B Alashkar Alhamwe, DP Potaczek, S Miethe… - International journal of …, 2021 - mdpi.com
Extracellular vesicles (EVs) are membranous structures, which are secreted by almost every
cell type analyzed so far. In addition to their importance for cell-cell communication under …

The role of epigenetics in allergy and asthma development

BA Alhamwe, F Alhamdan, A Ruhl… - Current opinion in …, 2020 - journals.lww.com
The role of epigenetics in allergy and asthma development : Current Opinion in Allergy and
Clinical Immunology The role of epigenetics in allergy and asthma development : Current …

[HTML][HTML] Indoor microbiome and allergic diseases: from theoretical advances to prevention strategies

X Fu, Z Ou, Y Sun - Eco-Environment & Health, 2022 - Elsevier
The prevalence of allergic diseases, such as asthma, rhinitis, eczema, and sick building
syndrome (SBS), has increased drastically in the past few decades. Current medications can …

Epigenetic regulation of airway epithelium immune functions in asthma

B Alashkar Alhamwe, S Miethe… - Frontiers in …, 2020 - frontiersin.org
Asthma is a chronic inflammatory disease of the respiratory tract characterized by recurrent
breathing problems resulting from airway obstruction and hyperresponsiveness. Human …