In the era of personalized medicine, insights into the molecular mechanisms that
differentially contribute to disease phenotypes, such as asthma phenotypes including …

Asthma is a major driver of health care costs across ages. Despite widely disseminated
asthma-treatment guidelines and a growing variety of effective therapeutic options, most …

Asthma is a complex trait, often associated with atopy. The genetic contribution has been
evidenced by familial occurrence. Genome-wide association studies allowed for associating …

Background Risk factors for the pathogenesis of chronic rhinosinusitis (CRS) remain largely
undetermined, which is likely due to the heterogeneity of the disease. White blood cell …

Sirtuins are NAD-dependent class III histone deacetylase, which modulate the epigenetic
changes to influence the functions in normal and diseased conditions. Preclinical studies …

Objective The aim of this study was to systematically review the evidence across studies that
assessed DNA methylome variations in association with food allergy (FA). Design A …

The epigenome is at the intersection of the environment, genotype, and cellular response.
DNA methylation of cytosine nucleotides, the most studied epigenetic modification, has been …

There has been a substantial increase in the incidence and the prevalence of allergic
disorders in the recent decades, which seems to be related to rapid environmental and …

abstract The ongoing COhort for Childhood Origin of Asthma and allergic diseases
(COCOA) study is a prospective birth cohort investigating the origin and natural courses of …

Asthma, allergic rhinitis, food allergy, and atopic dermatitis are common childhood diseases
with several different underlying mechanisms, ie, endotypes of disease. Metabolomics has …