Fibronectin is an extracellular matrix protein that is present during periods of change within
tissues. It is upregulated and necessary in a number of developmental contexts, and it is …

Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix,
where they interact with a plethora of ligands. Over the last decade, new insights have …

Sulfation is a dynamic and complex posttranslational modification process. It can occur at
various positions within the glycosaminoglycan (GAG) backbone and modulates …

The small intestinal villus tip is the first point of contact for lumen-derived substances
including nutrients and microbial products. Electron microscopy studies from the early 1970s …

Cells need to be anchored to extracellular matrix (ECM) to survive, yet the role of ECM in
guiding developmental processes, tissue homeostasis, and aging has long been …

The trabecular meshwork regulates aqueous humour outflow from the anterior chamber of
the eye. It does this by establishing a tunable outflow resistance, defined by the interplay …

The formation of atherosclerotic plaques in the large and medium sized arteries is classically
driven by systemic factors, such as elevated cholesterol and blood pressure. However, work …

It has recently been shown that some growth factors (GFs) have strong interactions with
nonproteoglycan extracellular matrix proteins. Relevant here, the 12th‐14th type three …

Angiogenesis is a multistep process driven by a wide range of positive and negative
regulatory factors. Extracellular matrix (ECM) plays a crucial role in the regulation of this …

Extracellular matrix (ECM)-mimicking biomaterials are considered effective tissue-
engineered scaffolds for regenerative medicine because of their biocompatibility …