Recent development of the molecular and cellular mechanisms of hydrogen sulfide gasotransmitter

J Liu, FM Mesfin, CE Hunter, KR Olson, WC Shelley… - Antioxidants, 2022 - mdpi.com
Hydrogen sulfide has been recently identified as the third biological gasotransmitter, along
with the more well studied nitric oxide (NO) and carbon monoxide (CO). Intensive studies on …

Protein S-sulfhydration: unraveling the prospective of hydrogen sulfide in the brain, vasculature and neurological manifestations

R Gupta, M Sahu, R Tripathi, RK Ambasta… - Ageing Research …, 2022 - Elsevier
Hydrogen sulfide (H 2 S) and hydrogen polysulfides (H 2 S n) are essential regulatory
signaling molecules generated by the entire body, including the central nervous system …

Post-translational modifications of Keap1: the state of the art

Y Song, Y Qu, C Mao, R Zhang, D Jiang… - Frontiers in Cell and …, 2024 - frontiersin.org
The Keap1-Nrf2 signaling pathway plays a crucial role in cellular defense against oxidative
stress-induced damage. Its activation entails the expression and transcriptional regulation of …

Luteolin Confers Cerebroprotection after Subarachnoid Hemorrhage by Suppression of NLPR3 Inflammasome Activation through Nrf2‐Dependent Pathway

ZH Zhang, JQ Liu, CD Hu, XT Zhao… - Oxidative Medicine …, 2021 - Wiley Online Library
Luteolin (LUT) possesses multiple biologic functions and has beneficial effects for
cardiovascular and cerebral vascular diseases. Here, we investigated the protective effects …

Echinocystic acid alleviated hypoxic-ischemic brain damage in neonatal mice by activating the PI3K/Akt/Nrf2 signaling pathway

Y Li, L Chen, D Zheng, JX Liu, C Liu, SH Qi… - Frontiers in …, 2023 - frontiersin.org
Neonatal hypoxic-ischemic encephalopathy (HIE) is considered a major cause of death and
long-term neurological injury in newborns. Studies have demonstrated that oxidative stress …

Electroacupuncture alleviates neuroinflammation by inhibiting the HMGB1 signaling pathway in rats with sepsis-associated encephalopathy

Y Xin, J Wang, T Chu, Y Zhou, C Liu, A Xu - Brain Sciences, 2022 - mdpi.com
Sepsis-Associated Encephalopathy (SAE) is common in sepsis patients, with high mortality
rates. It is believed that neuroinflammation is an important mechanism involved in SAE. High …

Gases in sepsis: novel mediators and therapeutic targets

Z Zhu, S Chambers, Y Zeng, M Bhatia - International Journal of Molecular …, 2022 - mdpi.com
Sepsis, a potentially lethal condition resulting from failure to control the initial infection, is
associated with a dysregulated host defense response to pathogens and their toxins. Sepsis …

Novel H2S-Releasing Bifunctional Antihistamine Molecules with Improved Antipruritic and Reduced Sedative Actions

I Antoniadou, M Georgiou, Y Dotsikas… - Journal of medicinal …, 2023 - ACS Publications
Hydrogen sulfide (H2S) is an endogenous gasotransmitter with anti-inflammatory actions
that also reduces itching. To test whether a combination of an antihistamine with a H2S …

Icariside II Attenuates Methamphetamine‐Induced Neurotoxicity and Behavioral Impairments via Activating the Keap1‐Nrf2 Pathway

J Huang, J Ding, Z Wang, Y Li, Y He… - Oxidative Medicine …, 2022 - Wiley Online Library
Chronic and long‐term methamphetamine (METH) abuse is bound to cause damages to
multiple organs and systems, especially the central nervous system (CNS). Icariside II (ICS) …

Hydrogen sulfide signaling in the tumor microenvironment: implications in cancer progression and therapy

JA Machado-Neto, ARA Cerqueira… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: Cancer is a complex and heterotypic structure with a spatial organization that
contributes to challenges in therapeutics. Enzymes associated with producing the …