Recent development of the molecular and cellular mechanisms of hydrogen sulfide gasotransmitter
Hydrogen sulfide has been recently identified as the third biological gasotransmitter, along
with the more well studied nitric oxide (NO) and carbon monoxide (CO). Intensive studies on …
with the more well studied nitric oxide (NO) and carbon monoxide (CO). Intensive studies on …
Protein S-sulfhydration: unraveling the prospective of hydrogen sulfide in the brain, vasculature and neurological manifestations
Hydrogen sulfide (H 2 S) and hydrogen polysulfides (H 2 S n) are essential regulatory
signaling molecules generated by the entire body, including the central nervous system …
signaling molecules generated by the entire body, including the central nervous system …
Post-translational modifications of Keap1: the state of the art
Y Song, Y Qu, C Mao, R Zhang, D Jiang… - Frontiers in Cell and …, 2024 - frontiersin.org
The Keap1-Nrf2 signaling pathway plays a crucial role in cellular defense against oxidative
stress-induced damage. Its activation entails the expression and transcriptional regulation of …
stress-induced damage. Its activation entails the expression and transcriptional regulation of …
Luteolin Confers Cerebroprotection after Subarachnoid Hemorrhage by Suppression of NLPR3 Inflammasome Activation through Nrf2‐Dependent Pathway
ZH Zhang, JQ Liu, CD Hu, XT Zhao… - Oxidative Medicine …, 2021 - Wiley Online Library
Luteolin (LUT) possesses multiple biologic functions and has beneficial effects for
cardiovascular and cerebral vascular diseases. Here, we investigated the protective effects …
cardiovascular and cerebral vascular diseases. Here, we investigated the protective effects …
Echinocystic acid alleviated hypoxic-ischemic brain damage in neonatal mice by activating the PI3K/Akt/Nrf2 signaling pathway
Y Li, L Chen, D Zheng, JX Liu, C Liu, SH Qi… - Frontiers in …, 2023 - frontiersin.org
Neonatal hypoxic-ischemic encephalopathy (HIE) is considered a major cause of death and
long-term neurological injury in newborns. Studies have demonstrated that oxidative stress …
long-term neurological injury in newborns. Studies have demonstrated that oxidative stress …
Electroacupuncture alleviates neuroinflammation by inhibiting the HMGB1 signaling pathway in rats with sepsis-associated encephalopathy
Y Xin, J Wang, T Chu, Y Zhou, C Liu, A Xu - Brain Sciences, 2022 - mdpi.com
Sepsis-Associated Encephalopathy (SAE) is common in sepsis patients, with high mortality
rates. It is believed that neuroinflammation is an important mechanism involved in SAE. High …
rates. It is believed that neuroinflammation is an important mechanism involved in SAE. High …
Gases in sepsis: novel mediators and therapeutic targets
Z Zhu, S Chambers, Y Zeng, M Bhatia - International Journal of Molecular …, 2022 - mdpi.com
Sepsis, a potentially lethal condition resulting from failure to control the initial infection, is
associated with a dysregulated host defense response to pathogens and their toxins. Sepsis …
associated with a dysregulated host defense response to pathogens and their toxins. Sepsis …
Novel H2S-Releasing Bifunctional Antihistamine Molecules with Improved Antipruritic and Reduced Sedative Actions
I Antoniadou, M Georgiou, Y Dotsikas… - Journal of medicinal …, 2023 - ACS Publications
Hydrogen sulfide (H2S) is an endogenous gasotransmitter with anti-inflammatory actions
that also reduces itching. To test whether a combination of an antihistamine with a H2S …
that also reduces itching. To test whether a combination of an antihistamine with a H2S …
Icariside II Attenuates Methamphetamine‐Induced Neurotoxicity and Behavioral Impairments via Activating the Keap1‐Nrf2 Pathway
J Huang, J Ding, Z Wang, Y Li, Y He… - Oxidative Medicine …, 2022 - Wiley Online Library
Chronic and long‐term methamphetamine (METH) abuse is bound to cause damages to
multiple organs and systems, especially the central nervous system (CNS). Icariside II (ICS) …
multiple organs and systems, especially the central nervous system (CNS). Icariside II (ICS) …
Hydrogen sulfide signaling in the tumor microenvironment: implications in cancer progression and therapy
JA Machado-Neto, ARA Cerqueira… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: Cancer is a complex and heterotypic structure with a spatial organization that
contributes to challenges in therapeutics. Enzymes associated with producing the …
contributes to challenges in therapeutics. Enzymes associated with producing the …