Constitutional BRCA1/BRCA2 pathogenic or likely pathogenic variants (PVs) are associated
with an increased risk for developing breast and ovarian cancers. Current evidence …

Simple Summary In this review, we present current knowledge about the prognostic and
predictive role of tumor-infiltrating lymphocytes (TILs) in ovarian cancer since this tumor …

Besides BRCA1 and BRCA2, several other inheritable mutations have been identified that
increase ovarian cancer risk. Surgical excision of the fallopian tubes and ovaries reduces …

Simple Summary For the small subset of pancreatic ductal adenocarcinoma (PDAC) patients
with loss-of-function mutations to BRCA1/2 or PALB2, both first-line and maintenance …

MUTYH gene is involved in the base excision repair (BER) mechanism and its pathogenic
alterations are associated with colorectal polyposis and cancer. MUTYH-associated …

Simple Summary Pancreatic cancer (PC) is one of the deadliest cancers. Its high mortality
rate is correlated with several explanations; the main one is the late disease stage at which …

Breast cancer susceptibility gene 1 (BRCA1) and breast cancer susceptibility gene 2
(BRCA2) deleterious variants were the first and, still today, the main biomarkers of poly …

Numerous variants of unknown significance (VUSs) exist in hereditary breast and ovarian
cancers. Although multiple methods have been developed to assess the significance of …

Background Elucidation of specific and recurrent/founder pathogenic variants (PVs) in
BRCA (BRCA1 and BRCA2) genes can make the genetic testing, for breast cancer (BC) …

Germline BRCA1/2 alterations in the Homologous Recombination (HR) pathway are
considered as main susceptibility biomarkers to Hereditary Breast and Ovarian Cancers …