Objective Our goal is to investigate if microbiota composition modulates reward signaling
and assess the role of the vagus in mediating microbiota to brain communication. Methods …

Abstract Glucagon-like peptide-1 (GLP-1) agonists have been successfully used in clinical
practice for the treatment of diabetes and obesity, offering significant clinical benefits …

Abstract Background As a traditional Chinese medicinal herb, the lipid-lowing biological
potential of Eucommia ulmoides leaves (EL) has been demonstrated. After fermentation, the …

Animal studies indicate that a high-fat/high-sugar diet (HFS) can change dopamine signal
transmission in the brain, which could promote maladaptive behavior and decision-making …

Methylmercury (MeHg) is a well-known neurotoxicant; however, its role in metabolic
diseases has been gaining wider attention. Chronic exposure to MeHg in human …

Obesity continues to rise in prevalence and financial burden despite strong evidence linking
it to an increased risk of developing several chronic diseases. Dopamine response and …

One of the largest health problems worldwide is the development of chronic
noncommunicable diseases due to the consumption of hypercaloric diets. Among the most …

Nicotine has been well-characterized for its ability to alter neurophysiology to promote
rewarding and reinforcing properties. However, several exogenous chemicals possess …

Diet-induced obesity (DIO) is associated with chronic, low-grade inflammation and
correlates with mood and psychological disorders (ie, depression and anxiety). Recent …

Reduced dopamine (DA) signaling has been hypothesized to induce compulsive overeating
in obesity. However, DA signaling facilitates food pursuit by acting on direct and indirect …