The Role of 17β-Estradiol and Estrogen Receptors in Regulation of Ca2+ Channels and Mitochondrial Function in Cardiomyocytes

S Mahmoodzadeh, E Dworatzek - Frontiers in Endocrinology, 2019 - frontiersin.org
Numerous epidemiological, clinical, and animal studies showed that cardiac function and
manifestation of cardiovascular diseases (CVDs) are different between males and females …

Estrogen and calcium handling proteins: new discoveries and mechanisms in cardiovascular diseases

L Jiao, JO Machuki, Q Wu, M Shi, L Fu… - American Journal …, 2020 - journals.physiology.org
Estrogen deficiency is considered to be an important factor leading to cardiovascular
diseases (CVDs). Indeed, the prevalence of CVDs in postmenopausal women exceeds that …

Protein phosphatase 1 in tumorigenesis: is it worth a closer look?

J Felgueiras, C Jerónimo, M Fardilha - Biochimica et Biophysica Acta (BBA) …, 2020 - Elsevier
Cancer cells take advantage of signaling cascades to meet their requirements for sustained
growth and survival. Cell signaling is tightly controlled by reversible protein phosphorylation …

Diosgenin attenuates myocardial cell apoptosis triggered by oxidative stress through estrogen receptor to activate the PI3K/Akt and ERK axes

MYC Chen, BCK Tsai, WW Kuo, CH Kuo… - The American Journal …, 2023 - World Scientific
Cardiovascular diseases in post-menopausal women are on a rise. Oxidative stress is the
main contributing factor to the etiology and pathogenesis of cardiovascular diseases …

Low doses of BPA induced abnormal mitochondrial fission and hypertrophy in human embryonic stem cell-derived cardiomyocytes via the calcineurin-DRP1 signaling …

W Cheng, S Yang, X Li, F Liang, R Zhou… - Toxicology and Applied …, 2020 - Elsevier
Humans are inevitably exposed to bisphenol A (BPA) via multiple exposure ways. Thus,
attention should be raised to the possible adverse effects related to low doses of BPA …

Serum testosterone level correlates with left ventricular hypertrophy in older women

I Szadkowska, A Guligowska, A Jegier… - Frontiers in …, 2023 - frontiersin.org
Introduction Sex hormones may play an important role in age-related cardiac remodeling.
However, their impact on cardiac structure and function in females of advanced age still …

The Effect of Estrogen on Intracellular Ca2+ and Na+ Regulation in Heart Failure

JM Firth, HY Yang, AJ Francis, N Islam… - Basic to Translational …, 2020 - jacc.org
Contradictory findings of estrogen supplementation in cardiac disease highlight the need to
investigate the involvement of estrogen in the progression of heart failure in an animal …

The combined inhibition of the CaMKIIδ and calcineurin signaling cascade attenuates IGF‐IIR‐induced cardiac hypertrophy

CH Chen, JW Lin, CY Huang, YL Yeh… - Journal of Cellular …, 2020 - Wiley Online Library
Cardiac hypertrophy is a common phenomenon observed in progressive heart disease
associated with heart failure. Insulin‐like growth factor receptor II (IGF‐IIR) has been much …

Cardiac CaMKIIδ and Wenxin Keli Prevents Ang II‐Induced Cardiomyocyte Hypertrophy by Modulating CnA‐NFATc4 and Inflammatory Signaling Pathways in H9c2 …

N An, Y Chen, Y Xing, H Wu, X Gao… - Evidence‐Based …, 2020 - Wiley Online Library
Previous studies have demonstrated that calcium‐/calmodulin‐dependent protein kinase II
(CaMKII) and calcineurin A‐nuclear factor of activated T‐cell (CnA‐NFAT) signaling …

Inhibitor 1 of Protein Phosphatase 1 Regulates Ca2+/Calmodulin‐Dependent Protein Kinase II to Alleviate Oxidative Stress in Hypoxia‐Reoxygenation Injury of …

H Luo, S Song, Y Chen, M Xu, L Sun… - Oxidative Medicine …, 2019 - Wiley Online Library
Ca2+/calmodulin‐dependent protein kinase II (CaMKII), regulated by inhibitor 1 of protein
phosphatase 1 (I1PP1), is vital for maintaining cardiovascular homeostasis. However, the …