Mitochondria are centers of energy metabolism. The mitochondrial network is shaped by
mitochondrial dynamics, including the processes of mitochondrial fission and fusion and …

Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic
targets based on neuronal protection, repair, or regeneration, independent of etiology or site …

Dominant optic atrophy is one of the leading causes of childhood blindness. Around 60–
80% of cases are caused by mutations of the gene that encodes optic atrophy protein 1 …

Historically, distinct mitochondrial syndromes were recognised clinically by their ocular
features. Due to their predilection for metabolically active tissue, mitochondrial diseases …

High-fat consumption promotes the development of obesity, which is associated with various
chronic illnesses. Mitochondria are the energy factories of eukaryotic cells, maintaining self …

Mitochondrial DNA (mtDNA) maintenance is critical for oxidative phosphorylation (OXPHOS)
since some subunits of the respiratory chain complexes are mitochondrially encoded …

In eukaryotes, mitochondrial RNAs (mt-tRNAs and mt-rRNAs) are subject to specific
nucleotide modifications, which are critical for distinct functions linked to the synthesis of …

Advancements in ocular imaging have significantly broadened our comprehension of
mitochondrial retinopathies and optic neuropathies by examining the structural and …

Manganese is an essential trace element, but overexposure can cause neurotoxicity and
subsequent neurodegenerative diseases. Ferroptosis is a form of cell death characterized …

Mitochondria are pleiotropic organelles central to an array of cellular pathways including
metabolism, signal transduction, and programmed cell death. Mitochondria are also key …