The endocannabinoid system, consisting of the cannabinoid 1 receptor (CB 1 R) and
cannabinoid 2 receptor (CB 2 R), endogenous cannabinoid ligands (endocannabinoids) …

The most important discoveries in pharmacology, such as certain classes of analgesics or
chemotherapeutics, started from natural extracts which have been found to have effects in …

The prefrontal cortex (PFC) provides executive control of the brain in humans and rodents,
coordinating cognitive, emotional, and behavioral responses to threatening stimuli and …

The prelimbic division (PrL) of the medial prefrontal cortex (mPFC) is a cerebral division that
is putatively implicated in the chronic pain and depression. We investigated the activity of …

The chronic constriction injury (CCI) of the sciatic nerve is a nerve injury‐based model of
neuropathic pain (NP). Comorbidities of NP such as depression, anxiety, and cognitive …

The mechanisms underlying chronic and neuropathic pain pathology involve peripheral and
central sensitisation. The medial prefrontal cortex (mPFC) seems to participate in pain …

Background Chronic constriction injury (CCI) is a model of neuropathic pain induced by four
loose ligatures around the sciatic nerve. This work aimed to investigate the sensory …

Electrical stimulation of the periaqueductal gray matter and ventromedial hypothalamus in
humans showed the involvement of both these structures in panic attacks. The aim of this …

Stress has a complex, bidirectional modulatory influence on pain. Stress may either reduce
(stress-induced analgesia) or exacerbate (stress-induced hyperalgesia) pain depending on …

Maternal behavior is a highly motivated and adaptive social behavior. Its frequency and
pattern change across the postpartum period in response to the changing characteristics of …