The endothelium lines the luminal surface of every blood vessel, allowing it contact with
circulating blood elements, as well as the underlying vascular smooth muscle layer. In …

Over the past two decades, the treatment of cancer has been revolutionised by the highly
successful introduction of novel molecular targeted therapies and immunotherapies …

It is generally held that the role of a specific control element can only be understood within
its physiological environment. The reviewed studies make it clear that there is a potent …

This article briefly reviews recent advances in knowledge of the histology and function of
blood vessels. It focuses upon the multifunctional roles of endothelium and smooth muscle …

Background Elevated protein kinase C (PKC) activity is thought to play a substantial role in
the aetiology of diabetic microvascular complications, the PKCβ isoform being identified as …

Impaired Ω-6 essential fatty acid metabolism and exaggerated polyol pathway flux contribute
to the neurovascular abnormalities in streptozotocin-diabetic rats. The potential interactions …

Pulmonary Hypertension (PH) is a multifactorial and lethal disease, characterised by
elevated pulmonary arterial pressure and progressive right heart failure. PH pathobiology …

Hypoxia decreases vasorelaxation and leads to pulmonary arterial hypertension. A newly
identified 52 amino-acid peptide adrenomedullin (ADM) exerts vasodilator effect in intact …

Introduction There is a growing need for small-diameter (< 6 mm) off-the-shelf synthetic
vascular conduits for different surgical bypass procedures, with actual synthetic conduits …

Mediators released from injured human skin that initiate the inflammatory response have not
been adequately identified. Organ culture of full-thickness skin explants enables us to do so …