Vascular endothelial cells and innate immunity

Y Shao, J Saredy, WY Yang, Y Sun, Y Lu… - … , and vascular biology, 2020 - Am Heart Assoc
In addition to the roles of endothelial cells (ECs) in physiological processes, ECs actively
participate in both innate and adaptive immune responses. We previously reported that, in …

Beneficial effects of citrus flavonoids on cardiovascular and metabolic health

AM Mahmoud, RJ Hernandez Bautista… - Oxidative medicine …, 2019 - Wiley Online Library
The prevalence of cardiovascular disease (CVD) is increasing over time. CVD is a
comorbidity in diabetes and contributes to premature death. Citrus flavonoids possess …

HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry

C Wei, L Wan, Q Yan, X Wang, J Zhang, X Yang… - Nature …, 2020 - nature.com
Responsible for the ongoing coronavirus disease 19 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells through binding of the …

Hypertriglyceridemia and atherosclerosis

J Peng, F Luo, G Ruan, R Peng, X Li - Lipids in health and disease, 2017 - Springer
Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death and it has
been confirmed that increased low density lipoprotein cholesterol (LDL-C) is an …

Targeting inflammation in metabolic syndrome

FK Welty, A Alfaddagh, TK Elajami - Translational research, 2016 - Elsevier
The metabolic syndrome (MetS) is comprised of a cluster of closely related risk factors,
including visceral adiposity, insulin resistance, hypertension, high triglyceride, and low high …

An abundant dysfunctional apolipoprotein A1 in human atheroma

Y Huang, JA DiDonato, BS Levison, D Schmitt, L Li… - Nature medicine, 2014 - nature.com
Recent studies have indicated that high-density lipoproteins (HDLs) and their major
structural protein, apolipoprotein A1 (apoA1), recovered from human atheroma are …

High-density lipoprotein: vascular protective effects, dysfunction, and potential as therapeutic target

TF Lüscher, U Landmesser, A von Eckardstein… - Circulation …, 2014 - Am Heart Assoc
High-density lipoprotein (HDL) is a complex mixture of lipoproteins that is associated with
many minor proteins and lipids that influence the function of HDL. Although HDL is a …

Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis

DE Gaddis, LE Padgett, R Wu, C McSkimming… - Nature …, 2018 - nature.com
Regulatory T (Treg) cells contribute to the anti-inflammatory response during atherogenesis.
Here we show that during atherogenesis Treg cells lose Foxp3 expression and their …

The ins and outs of lipid rafts: Functions in intracellular cholesterol homeostasis, microparticles, and cell membranes: Thematic Review Series: Biology of Lipid Rafts

AB Ouweneel, MJ Thomas, MG Sorci-Thomas - Journal of lipid research, 2020 - ASBMB
Cellular membranes are not homogenous mixtures of proteins; rather, they are segregated
into microdomains on the basis of preferential association between specific lipids and …

How do elevated triglycerides and low HDL-cholesterol affect inflammation and atherothrombosis?

FK Welty - Current cardiology reports, 2013 - Springer
This review article summarizes recent research into the mechanisms as to how elevated
levels of triglyceride (TG) and low levels of high-density-lipoprotein cholesterol (HDL-C) …