Inflammation and its resolution is under-studied in medicine despite being essential for
understanding the development of chronic inflammatory disease. In this review article, we …

Asthma is a common disease that affects 300 million people worldwide. Given the large
number of eosinophils in the airways of people with mild asthma, and verified by data from …

Abstract The interleukin 12 (IL-12) family is unique in having the only heterodimeric
cytokines, including IL-12, IL-23, IL-27 and IL-35. This feature endows these cytokines with a …

Dendritic cells (DCs) are a heterogeneous population playing a pivotal role in immune
responses and tolerance. DCs promote immune tolerance by participating in the negative …

Recent studies have reported the pathological effect of ICOS+ T cells, but ICOS signals also
widely participate in anti-inflammatory responses, particularly ICOS+ regulatory T (Treg) …

Abstract Foxp3+ regulatory T (Treg) cells expressing the interleukin (IL)-33 receptor ST2
mediate tissue repair in response to IL-33. Whether Treg cells also respond to the alarmin IL …

Regulatory T (Treg) cells are a heterogenous population of immunosuppressive T cells
whose therapeutic potential for the treatment of autoimmune diseases and graft rejection is …

Innate immune cells, particularly macrophages and epithelial cells, play a key role in
multiple layers of immune responses. Alarmins and pro-inflammatory cytokines from the IL …

Acute respiratory distress syndrome/acute lung injury (ALI) was described in 1967. The
uncontrolled inflammation is a central issue of the syndrome. The regulatory T cells (Tregs) …

The respiratory tract is an important site of immune regulation; required to allow protective
immunity against pathogens, while minimizing tissue damage and avoiding aberrant …