Nucleoside analogues have been in clinical use for almost 50 years and have become
cornerstones of treatment for patients with cancer or viral infections. The approval of several …

Treatment of chronic hepatitis C virus (HCV) infection with direct-acting antiviral agents
(DAA) is associated with high rates of sustained virologic response. Remaining factors …

The CRISPR effector Cas13 could be an effective antiviral for single-stranded RNA (ssRNA)
viruses because it programmably cleaves RNAs complementary to its CRISPR RNA …

The global scale-up of antiretroviral (ARV) therapy (ART) has led to dramatic reductions in
HIV-1 mortality and incidence. However, HIV drug resistance (HIVDR) poses a potential …

Abstract Model-based analyses of natural selection often categorize sites into a relatively
small number of site classes. Forcing each site to belong to one of these classes places …

Background Despite the growing number of people on antiretroviral therapy (ART), there is
limited information about virological non-suppression and its determinants among HIV …

Introduction: Human immunodeficiency virus (HIV) type-1 non-nucleoside and nucleoside
reverse transcriptase inhibitors (NNRTIs) are key drugs of highly active antiretroviral therapy …

Despite advances in antiretroviral therapy that have revolutionized HIV disease
management, effective control of the HIV infection pandemic remains elusive. Beyond the …

The introduction of potent combination therapies in the mid-90s had a tremendous effect on
AIDS mortality. However, drug resistance has been a major factor contributing to …

Introduction: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are essential
components of highly active antiretroviral therapy against HIV-1 infections. Here, we provide …