Abstract Changes in classical and nonclassical HLA class I as well as HLA class II antigens
have been identified in malignant lesions. These changes, which are described in this …

The genome is programmed by the epigenome. Two of the fundamental components of the
epigenome are chromatin structure and covalent modification of the DNA molecule itself by …

DNA methylation is an epigenetic mechanism for gene silencing engaged by DNA
methyltransferase (Dnmt)-catalyzed methyl group transfer to cytosine residues in gene …

How DNA methylation patterns are established, maintained and remodeled is incompletely
understood, however, it has become clear that DNA methylation is reversible and dynamic …

Cytosine methylation is an epigenetic mark that promotes gene silencing and plays
important roles in development and genome defense against transposons. Methylation …

The hallmarks of carcinogenesis are aberrations in gene expression and protein function
caused by both genetic and epigenetic modifications. Epigenetics refers to the changes in …

Cortisol is the main glucocorticoid (GC) in fish and the hormone most directly associated
with stress. Recent research suggests that this hormone may act as a key factor linking …

People differ in their requirements for and responses to nutrients and bioactive molecules in
the diet. Many inputs contribute to metabolic heterogeneity (including variations in genetics …

It is becoming increasingly clear that a dysfunction of the GABAergic/glutamatergic network
in telencephalic brain structures may be the pathogenetic mechanism underlying psychotic …

Purpose: We utilized whole-genome mapping of promoters that are activated by DNA
hypomethylation in hepatocellular carcinoma (HCC) clinical samples to shortlist novel …