RNA adopts 3D structures that confer varied functional roles in human biology and
dysfunction in disease. Approaches to therapeutically target RNA structures with small …

Protein–RNA interactions have crucial roles in various cellular activities, which, when
dysregulated, can lead to a range of human diseases. The identification of small molecules …

The recently discovered functions of RNA dramatically expand the cellular roles for this
macromolecule. RNA can no longer be viewed as a passive element, working simply as an …

Single-nucleotide polymorphisms (SNPs) are the most common type of genetic variation in
man. Genes containing one or more SNPs can give rise to two or more allelic forms of …

Activation of cellular genes typically involves control of transcription initiation by DNA-
binding regulatory proteins. The human immunodeficiency virus transactivator protein, Tat …

Highly conserved noncoding RNA (ncRNA) elements in viral genomes and transcripts offer
new opportunities to expand the repertoire of drug targets for the development of …

The surprising discovery that RNAs are the predominant gene products to emerge from the
human genome catalyzed a renaissance in RNA biology. It is now well-understood that …

The recognition of RNA functions beyond canonical protein synthesis has challenged the
central dogma of molecular biology. Indeed, RNA is now known to directly regulate many …

Researchers' increasing awareness of the essential role played by RNA in many biological
processes and in the progression of disease makes the discovery of new RNA targets an …

Although most antibiotics do not need metal ions for their biological activities, there are a
number of antibiotics that require metal ions to function properly, such as bleomycin (BLM) …