[HTML][HTML] Current treatment paradigms and emerging therapies for NAFLD/NASH
S Raza, S Rajak, A Upadhyay, A Tewari… - Frontiers in bioscience …, 2021 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) is one the fastest emerging manifestations of the
metabolic syndrome worldwide. Non-alcoholic steatohepatitis (NASH), the progressive form …
metabolic syndrome worldwide. Non-alcoholic steatohepatitis (NASH), the progressive form …
PPAR-γ signaling in nonalcoholic fatty liver disease: Pathogenesis and therapeutic targets
H Chen, H Tan, J Wan, Y Zeng, J Wang… - Pharmacology & …, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD), currently the leading cause of global chronic liver
disease, has emerged as a major public health problem, more efficient therapeutics of which …
disease, has emerged as a major public health problem, more efficient therapeutics of which …
[HTML][HTML] Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling
J Zhong, X He, X Gao, Q Liu, Y Zhao, Y Hong… - Nature …, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is usually characterized with disrupted bile acid
(BA) homeostasis. However, the exact role of certain BA in NAFLD is poorly understood …
(BA) homeostasis. However, the exact role of certain BA in NAFLD is poorly understood …
PPARγ signaling and metabolism: the good, the bad and the future
Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear
receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral …
receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral …
[HTML][HTML] History of nonalcoholic fatty liver disease
Based on the assumption that characterizing the history of a disease will help in improving
practice while offering a clue to research, this article aims at reviewing the history of …
practice while offering a clue to research, this article aims at reviewing the history of …
PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis
S Francque, A Verrijken, S Caron, J Prawitt… - Journal of …, 2015 - Elsevier
Background & Aims Peroxisome proliferator-activated receptors (PPARs) have been
implicated in non-alcoholic steatohepatitis (NASH) pathogenesis, mainly based on animal …
implicated in non-alcoholic steatohepatitis (NASH) pathogenesis, mainly based on animal …
[PDF][PDF] Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites
BA Neuschwander‐Tetri - Hepatology, 2010 - Wiley Online Library
With nonalcoholic steatohepatitis (NASH), NASH cirrhosis, and NASH-related hepatocellular
carcinoma becoming increasingly prevalent, the need for effective therapies has never been …
carcinoma becoming increasingly prevalent, the need for effective therapies has never been …
[HTML][HTML] Current efforts and trends in the treatment of NASH
Of all the aspects of non-alcoholic fatty liver disease (NAFLD), the slowest advances have
occurred in the therapeutic field. Thirty-five years after its formal description and after 15 …
occurred in the therapeutic field. Thirty-five years after its formal description and after 15 …
Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)
G Musso, R Gambino, M Cassader - Progress in lipid research, 2009 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in
Western countries and is considered the hepatic manifestation of metabolic syndrome. The …
Western countries and is considered the hepatic manifestation of metabolic syndrome. The …
Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis
N Anderson, J Borlak - Pharmacological reviews, 2008 - ASPET
Steatosis of the liver may arise from a variety of conditions, but the molecular basis for lipid
droplet formation is poorly understood. Although a certain amount of lipid storage may even …
droplet formation is poorly understood. Although a certain amount of lipid storage may even …