Systemic corticosteroid use to manage uncontrolled asthma and its associated healthcare
burden may account for important health-related adverse effects. We conducted a systematic …

Asthma is a common complex disease of the airways. Genome-wide association studies
(GWASs) of asthma have identified many risk alleles and loci that have been replicated in …

Background A serious adverse effect of corticosteroid therapy is adrenal suppression. Our
aim was to identify genetic variants affecting susceptibility to corticosteroid-induced adrenal …

The purpose of this study was to evaluate the effect of generation and surface PEGylation of
degradable polyester-based dendrimers nanocarriers on their interactions with an in vitro …

A 'one-size fits all'-approach does not fit all pediatric asthma patients. Current evidence
suggests that in children with persistent asthma, ADRB2 genotype-guided treatment can …

Perception of asthma can affect the patient's self-management and outcome treatment. The
outcome is not only determined by symptoms, but also by illness perception. Omega-3 in fish …

Objective Omics, aka multi-omics, is an emerging area of research that is advancing the use
of personalized medicine in clinical practice and is therefore relevant for the practicing …

Introduction Older adults have the greatest burden of asthma and poorest outcomes. The
pharmacogenetics of inhaled corticosteroid (ICS) treatment response is not well studied in …

Background Inhaled corticosteroids (ICSs) are the preferred treatment for achieving asthma
control. However, little is known regarding the factors contributing to treatment response and …

Heterogeneity defines both the natural history of asthma as well as patient's response to
treatment. Pharmacogenomics contribute to understand the genetic basis of drug response …