Dysregulated growth hormone (GH) hypersecretion is usually caused by a GH-secreting
pituitary adenoma and leads to acromegaly—a disorder of disproportionate skeletal, tissue …

Pituitary adenomas may hypersecrete hormones (including prolactin, growth hormone and
adrenocorticotropic hormone, and rarely follicle-stimulating hormone, luteinizing hormone or …

Although most pituitary tumors are benign, some are invasive or aggressive. In the absence
of specific markers of malignancy, only tumors with metastases are considered malignant …

Context: MicroRNAs (miRNAs) are small noncoding RNAs, functioning as antisense
regulators of gene expression by targeting mRNA and contributing to cancer development …

Mutations in DKC1, encoding for dyskerin, a pseudouridine synthase that modifies rRNA
and regulates telomerase activity, are associated with ribosomal dysfunction and increased …

Advances in precision molecular imaging promise to transform our ability to detect, diagnose
and treat disease. Here, we describe the engineering and validation of a new cystine knot …

Abstract MicroRNAs (miRs) are small, 16–29 nucleotide long, non-coding RNA molecules
which regulate the stability or translational efficiency of targeted mRNAs via RNA …

The anterior pituitary gland has the ability to respond to complex signals derived from central
and peripheral systems. Perception of these signals and their integration are mediated by …

Context: MEG3 is an imprinted gene encoding a novel noncoding RNA that suppresses
tumor cell growth. Although highly expressed in the normal human pituitary, it is unknown …

Context: The somatic landscape of pituitary adenomas is largely unknown. Identification of
somatic alterations aims at better understanding of tumor pathology. Objective: The objective …