Combined oral contraceptives (COCs) induce several changes in the levels of coagulation
factors. The levels of procoagulant factors are often increased, while levels of anticoagulant …

Hemostasis is a complex process in which abnormalities can cause shifts toward
prothrombotic or prohemorrhagic states resulting in thrombosis or bleeding, respectively …

Background: The endothelial cell–dependent PC (protein C) pathway is critically involved in
the regulation of coagulation, anti-inflammatory, and cytoprotective signaling. Its reactivity …

Rationale: Carriers of the most common prothrombotic mutations FVL (factor V Leiden) and
FII (prothrombin) 20210G> A show a highly variable clinical phenotype. Using standardized …

Aim: Feedback activation of factor XI (FXI) by thrombin is believed to play a critical role in the
amplification phase of thrombin generation and to contribute to thrombosis development and …

Background Recently we have shown alterations in the anticoagulant response to
recombinant activated factor VII (rFVIIa)-induced coagulation activation in thrombophilia …

Cardiovascular disease is the most frequent non-malignant cause of morbidity and mortality
in adult survivors of childhood or adolescent cancer. Thrombin generation (TG) analysis …

Inactivation of thrombin by the endogenous inhibitor antithrombin (AT) is a central
mechanism in the regulation of hemostasis. This makes hereditary AT deficiency, which is …

Background: Recently we have shown alterations in the anticoagulant response to
recombinant activated factor VII (rFVIIa)-induced coagulation activation in patients with …

Цель исследования: изучить показатели гемостаза у женщин с гиперандрогенией (ГА)
и нарушениями менструального цикла (НМЦ) на фоне приема комбинированного …