Neuronal plasticity produces changes in excitability, synaptic transmission, and network
architecture in response to external stimuli. Network adaptation to environmental conditions …

In the last decade, the fruit fly Drosophila melanogaster, highly accessible to genetic,
behavioral and molecular analyses, has been introduced as a novel model organism to help …

It is well established that behavioral sensitization to cocaine is accompanied by increased
spine density and AMPA receptor (AMPAR) transmission in the nucleus accumbens (NAc) …

Methamphetamine use disorder (MUD) is a neuropsychiatric disorder characterized by
binge drug taking episodes, intervals of abstinence, and relapses to drug use even during …

Actin is highly enriched at dendritic spines, and actin remodeling plays an essential role in
structural plasticity. The mammalian target of rapamycin complex 2 (mTORC2) is a regulator …

A high rate of relapse is a defining characteristic of substance use disorder for which few
treatments are available. Exposure to environmental cues associated with previous drug use …

This study examined the role of group1 metabotropic glutamate receptor mGluR5 and
associated postsynaptic scaffolding protein Homer1b/c in behavioral plasticity after three …

Aversive memories associated with drug withdrawal may contribute to persistent drug
seeking. Molecular mechanisms that are critical for aversive memory formation have yet to …

To identify candidate proteins in the nucleus accumbens (NAc) as potential
pharmacotherapeutic targets for treating cocaine addition, an 8-plex iTRAQ (isobaric tag for …

Glutamate signaling in prefrontal cortex and ventral tegmental area plays an important role
in the molecular and behavioral plasticity associated with addiction to drugs of abuse. The …