Advances in anti-cancer immunotherapy: Car-T cell, checkpoint inhibitors, dendritic cell vaccines, and oncolytic viruses, and emerging cellular and molecular targets
E Alard, AB Butnariu, M Grillo, C Kirkham, DA Zinovkin… - Cancers, 2020 - mdpi.com
Unlike traditional cancer therapies, such as surgery, radiation and chemotherapy that are
typically non-specific, cancer immunotherapy harnesses the high specificity of a patient's …
typically non-specific, cancer immunotherapy harnesses the high specificity of a patient's …
Neoantigen-targeted dendritic cell vaccination in lung cancer patients induces long-lived T cells exhibiting the full differentiation spectrum
J Ingels, L De Cock, D Stevens, RL Mayer, F Théry… - Cell Reports …, 2024 - cell.com
Non-small cell lung cancer (NSCLC) is known for high relapse rates despite resection in
early stages. Here, we present the results of a phase I clinical trial in which a dendritic cell …
early stages. Here, we present the results of a phase I clinical trial in which a dendritic cell …
Dendritic cell-based immunotherapy of malignant gliomas
P Parajuli, AE Sloan - Cancer investigation, 2004 - Taylor & Francis
The failure of conventional treatment modalities for gliomas, in spite of tremendous progress
in research in the past two decades, has led to increasing interest in alternative treatment …
in research in the past two decades, has led to increasing interest in alternative treatment …
Poly-L-arginine synergizes with oligodeoxynucleotides containing CpG-motifs (CpG-ODN) for enhanced and prolonged immune responses and prevents the CpG …
K Lingnau, A Egyed, C Schellack, F Mattner, M Buschle… - Vaccine, 2002 - Elsevier
This study describes an entirely synthetic vaccine composed of antigenic peptides (T cell
epitopes), oligodeoxynucleotides containing CpG-motifs (CpG-ODN) and poly-l-arginine …
epitopes), oligodeoxynucleotides containing CpG-motifs (CpG-ODN) and poly-l-arginine …
Systematic comparison of dendritic cell-based immunotherapeutic strategies for malignant gliomas: in vitro induction of cytolytic and natural killer-like T cells
P Parajuli, S Mathupala, AE Sloan - Neurosurgery, 2004 - journals.lww.com
OBJECTIVE: To compare the efficacy of various immunotherapeutic strategies of loading
dendritic cells (DCs) with whole-glioma cell antigens and characterize the effector …
dendritic cells (DCs) with whole-glioma cell antigens and characterize the effector …
Transfection of human monocyte-derived dendritic cells with native tumor DNA induces antigen-specific T-cell responses in vitro.
E Artusio, B Hathaway, J Stanson… - Cancer biology & …, 2006 - Taylor & Francis
Objective: Nucleofection of genomic tumor (Tu) DNA into human monocyte-derived dendritic
cells (hMoDC) was evaluated for use in producing anti-tumor vaccines able to induce …
cells (hMoDC) was evaluated for use in producing anti-tumor vaccines able to induce …
Maturation of dendritic cells in the presence of living, apoptotic and necrotic tumour cells derived from squamous cell carcinoma of head and neck
L Kacani, M Wurm, I Schwentner, J Andrle… - Oral oncology, 2005 - Elsevier
Dendritic cells (DC) have been recently used as vaccines for stimulation of tumour-specific
immunity in various types of cancer. Since data about interactions of DC with tumour cells …
immunity in various types of cancer. Since data about interactions of DC with tumour cells …
Systematic evaluation of the conditions required for the generation of immature rat bone marrow-derived dendritic cells and their phenotypic and functional …
M Muthana, B Fairburn, S Mirza, LK Slack… - Journal of …, 2004 - Elsevier
This study systematically evaluated the conditions required for generating immature rat bone
marrow-derived dendritic cells (BMDCs) and characterized their phenotype. The culture of …
marrow-derived dendritic cells (BMDCs) and characterized their phenotype. The culture of …
Dendritic cells and HNSCC: a potential treatment option?
G Dunn, KM Oliver, D Loke, ND Stafford… - Oncology …, 2005 - spandidos-publications.com
Patient survival in head and neck squamous cell cancer (HNSCC) has not changed
significantly in many years, despite progress in surgical, radiotherapy and chemotherapy …
significantly in many years, despite progress in surgical, radiotherapy and chemotherapy …
Human autologous dendritic cell-glioma fusions: feasibility and capacity to stimulate T cells with proliferative and cytolytic activity
AE Sloan, P Parajuli - Journal of neuro-oncology, 2003 - Springer
Gliomas are the most common primary neoplasm of the central nervous system. The failure
of conventional treatment modalities to improve outcome over the last two decades has led …
of conventional treatment modalities to improve outcome over the last two decades has led …