Control of satellite cell function in muscle regeneration and its disruption in ageing
P Sousa-Victor, L García-Prat… - … Reviews Molecular Cell …, 2022 - nature.com
Skeletal muscle contains a designated population of adult stem cells, called satellite cells,
which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically …
which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically …
[HTML][HTML] Skeletal muscle extracellular matrix–what do we know about its composition, regulation, and physiological roles? A narrative review
Skeletal muscle represents the largest body-composition component in humans. In addition
to its primary function in the maintenance of upright posture and the production of …
to its primary function in the maintenance of upright posture and the production of …
Making muscle: skeletal myogenesis in vivo and in vitro
J Chal, O Pourquié - Development, 2017 - journals.biologists.com
Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative
properties results in debilitating musculoskeletal disorders. Understanding the mechanisms …
properties results in debilitating musculoskeletal disorders. Understanding the mechanisms …
The jam session between muscle stem cells and the extracellular matrix in the tissue microenvironment
M Loreti, A Sacco - NPJ Regenerative medicine, 2022 - nature.com
Skeletal muscle requires a highly orchestrated coordination between multiple cell types and
their microenvironment to exert its function and to maintain its homeostasis and regenerative …
their microenvironment to exert its function and to maintain its homeostasis and regenerative …
[PDF][PDF] A human skeletal muscle atlas identifies the trajectories of stem and progenitor cells across development and from human pluripotent stem cells
The developmental trajectory of human skeletal myogenesis and the transition between
progenitor and stem cell states are unclear. We used single-cell RNA sequencing to profile …
progenitor and stem cell states are unclear. We used single-cell RNA sequencing to profile …
Generation of human muscle fibers and satellite-like cells from human pluripotent stem cells in vitro
J Chal, Z Al Tanoury, M Hestin, B Gobert, S Aivio… - Nature protocols, 2016 - nature.com
Progress toward finding a cure for muscle diseases has been slow because of the absence
of relevant cellular models and the lack of a reliable source of muscle progenitors for …
of relevant cellular models and the lack of a reliable source of muscle progenitors for …
Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice
L Lukjanenko, MJ Jung, N Hegde… - Nature medicine, 2016 - nature.com
Age-related changes in the niche have long been postulated to impair the function of
somatic stem cells. Here we demonstrate that the aged stem cell niche in skeletal muscle …
somatic stem cells. Here we demonstrate that the aged stem cell niche in skeletal muscle …
[PDF][PDF] Aged stem cells reprogram their daily rhythmic functions to adapt to stress
G Solanas, FO Peixoto, E Perdiguero, M Jardí… - Cell, 2017 - cell.com
Normal homeostatic functions of adult stem cells have rhythmic daily oscillations that are
believed to become arrhythmic during aging. Unexpectedly, we find that aged mice remain …
believed to become arrhythmic during aging. Unexpectedly, we find that aged mice remain …
[HTML][HTML] Regulation and phylogeny of skeletal muscle regeneration
MB Baghdadi, S Tajbakhsh - Developmental biology, 2018 - Elsevier
One of the most fascinating questions in regenerative biology is why some animals can
regenerate injured structures while others cannot. Skeletal muscle has a remarkable …
regenerate injured structures while others cannot. Skeletal muscle has a remarkable …
[PDF][PDF] Hic1 defines quiescent mesenchymal progenitor subpopulations with distinct functions and fates in skeletal muscle regeneration
Many adult tissues contain resident stem cells, such as the Pax7+ satellite cells within
skeletal muscle, that regenerate parenchymal elements following damage. Tissue-resident …
skeletal muscle, that regenerate parenchymal elements following damage. Tissue-resident …