One of the most fascinating questions in regenerative biology is why some animals can
regenerate injured structures while others cannot. Skeletal muscle has a remarkable …

The extracellular matrix (ECM) is an interconnected macromolecular scaffold occupying the
space between cells. Amongst other functions, the ECM provides structural support to …

Stem cell therapies have made great progress in the treatment of diabetic wounds during
recent decades, while their short in vivo residence, alloimmune reactions, undesired …

Skeletal muscle stem and progenitor cells including those derived from human pluripotent
stem cells (hPSCs) offer an avenue towards personalized therapies and readily fuse to form …

Human pluripotent stem cells (hPSCs) can be directed to differentiate into skeletal muscle
progenitor cells (SMPCs). However, the myogenicity of hPSC-SMPCs relative to human fetal …

Stem cells hold great promise in treating many diseases either through promoting
endogenous cell repair or through direct cell transplants. In order to maximize their potential …

Adult skeletal muscle has a robust capacity for self-repair, owing to synergies between
muscle satellite cells and the immune system. In vitro models of muscle self-repair would …

Necroptosis, a form of programmed cell death, is characterized by the loss of membrane
integrity and release of intracellular contents, the execution of which depends on the …

The extracellular matrix (ECM) is a complex network of biomolecules that mechanically and
biochemically directs cell behavior and is crucial for maintaining tissue function and health …

The cellular turnover required for skeletal muscle maintenance and repair is mediated by
resident stem cells, also termed satellite cells. Satellite cells normally reside in a quiescent …