Human induced pluripotent stem cells (hiPS cells or hiPSCs) can be derived from cells of
patients with severe muscle disease. If skeletal muscle induced from patient-iPSCs shows …

Muscle regeneration is mediated by the activity of resident muscle satellite cells (muSCs)
that express Pax7. In mouse Notch signaling regulates muSCs during quiescence and …

Skeletal muscle degeneration is responsible for major mobility complications, and this
muscle type has little regenerative capacity. Several biomaterials have been proposed to …

During ageing, adult stem cells' regenerative properties decline, as they undergo replicative
senescence and lose both their proliferative and differentiation capacities. In contrast …

Deficiency of laminin α2 chain leads to a severe form of congenital muscular dystrophy
(LAMA2-CMD), and dystrophic symptoms progress rapidly in early childhood. Currently …

Biomaterials that replicate patterns of microenvironmental signals from the stem cell niche
offer the potential to refine platforms to regulate stem cell behavior. While significant …

Aged muscles accumulate satellite cells with a striking decline response to damage.
Although intrinsic defects in satellite cells themselves are the major contributors to aging …

Adult stem cells occupy a niche that contributes to their function, but how stem cells rebuild
their microenvironment after injury remains an open‐ended question. Herein, biomaterial …

Human pluripotent stem cells (hPSCs) provide a human model for developmental
myogenesis, disease modeling and development of therapeutics. Differentiation of hPSCs …

Background: The injection of mesenchymal stem cells (MSCs) mitigates fat accumulation in
released rotator cuff muscle after tendon repair in rodents. Purpose: To investigate whether …