The mechanistic target of Rapamycin (mTOR) is a ubiquitously-conserved serine/threonine
kinase, which has a central function in integrating growth signals and orchestrating their …

Improvements in surgical techniques and availability of immunosuppressive options have
led to current successes in the arena of solid organ transplantation. Historically …

Cochrane, Maria Crespo Leiro, Anne Dipchand, Brian Feingold, Kathleen Grady, Edward
Horn, Maryl Johnson, Donna Mancini, Sean Pinney, Heather Ross, Kari Wujcik, Andreas …

Even in healthy aging, cardiac morbidity and mortality increase with age in both mice and
humans. These effects include a decline in diastolic function, left ventricular hypertrophy …

The advancement in pharmaceutical research has led to the discovery and development of
new combinatorial life-saving drugs. Rapamycin is a macrolide compound produced from …

Objectives: This study investigated temporal changes in the demographics and the
prognosis of cardiac allograft vasculopathy (CAV) over 30 years following heart …

Advances in immunosuppression have been a key component to the ongoing success of
lung transplantation. The demographics of patients receiving a lung transplant have evolved …

Background. Chronic kidney disease (CKD) after lung transplantation is common and limits
the survival of transplant recipients. The calcineurin inhibitors (CNI), cyclosporine A, and …

Immunosuppression management after lung transplantation continues to evolve, with an
increasing number of agents available for use in various combinations allowing for more …

Lung transplantation (LTx) has evolved significantly since its inception and the improvement
in LTx outcomes over the last three decades has predominantly been driven by advances in …