The role of plant‐derived natural antioxidants in reduction of oxidative stress

B Akbari, N Baghaei‐Yazdi, M Bahmaie… - …, 2022 - Wiley Online Library
Free radicals are a group of damaging molecules produced during the normal metabolism of
cells in the human body. Exposure to ultraviolet radiation, cigarette smoking, and other …

[HTML][HTML] Natural products in drug discovery: advances and opportunities

AG Atanasov, SB Zotchev, VM Dirsch… - Nature reviews Drug …, 2021 - nature.com
Natural products and their structural analogues have historically made a major contribution
to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural …

[HTML][HTML] Synergy and antagonism in natural product extracts: when 1+ 1 does not equal 2

LK Caesar, NB Cech - Natural product reports, 2019 - pubs.rsc.org
Covering: 2000 to 2019 According to a 2012 survey from the Centers for Disease Control
and Prevention, approximately 18% of the US population uses natural products (including …

Drug combinations: a strategy to extend the life of antibiotics in the 21st century

M Tyers, GD Wright - Nature Reviews Microbiology, 2019 - nature.com
Antimicrobial resistance threatens a resurgence of life-threatening bacterial infections and
the potential demise of many aspects of modern medicine. Despite intensive drug discovery …

[HTML][HTML] Actinobacteria in natural products research: Progress and prospects

PA Jose, A Maharshi, B Jha - Microbiological research, 2021 - Elsevier
Actinobacteria are well-recognised biosynthetic factories that produce an extensive
spectrum of secondary metabolites. Recent genomic insights seem to impact the exploitation …

Bioactivity-based molecular networking for the discovery of drug leads in natural product bioassay-guided fractionation

LF Nothias, M Nothias-Esposito… - Journal of natural …, 2018 - ACS Publications
It is a common problem in natural product therapeutic lead discovery programs that despite
good bioassay results in the initial extract, the active compound (s) may not be isolated …

Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities

LK Caesar, R Montaser, NP Keller… - Natural product reports, 2021 - pubs.rsc.org
Covering: 2010 to 2021 Organisms in nature have evolved into proficient synthetic chemists,
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …

[HTML][HTML] Advanced methods for natural products discovery: bioactivity screening, dereplication, metabolomics profiling, genomic sequencing, databases and informatic …

SP Gaudêncio, E Bayram, L Lukić Bilela, M Cueto… - Marine drugs, 2023 - mdpi.com
Natural Products (NP) are essential for the discovery of novel drugs and products for
numerous biotechnological applications. The NP discovery process is expensive and time …

[HTML][HTML] Plant metabolomics: a new strategy and tool for quality evaluation of Chinese medicinal materials

Q Xiao, X Mu, J Liu, B Li, H Liu, B Zhang, P Xiao - Chinese Medicine, 2022 - Springer
The present quality control method of Chinese medicinal materials (CMM) has obvious
deficiency, which cannot be compatible with the multi-target and multi-component …

[HTML][HTML] Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria

T Hoffmann, D Krug, N Bozkurt, S Duddela… - Nature …, 2018 - nature.com
Some bacterial clades are important sources of novel bioactive natural products. Estimating
the magnitude of chemical diversity available from such a resource is complicated by issues …