The power of any genetic model organism is derived, in part, from the ease with which gene
expression can be manipulated. The short generation time and invariant developmental …

A central feature of the continuum of life in sexually reproducing metazoans is the cycle of
the germline from one generation to the next. This volume describes the cycle of the …

Piwi-interacting RNAs (piRNAs) silence transposons to safeguard genome integrity in
animals. However, the functions of the many piRNAs that do not map to transposons remain …

Although individuals age and die with time, an animal species can continue indefinitely,
because of its immortal germ-cell lineage. How the germline avoids transmitting damage …

A hallmark of polarized cells is the segregation of the PAR polarity regulators into
asymmetric domains at the cell cortex,. Antagonistic interactions involving two conserved …

The evolutionary fate of an allele ordinarily depends on its contribution to host fitness.
Occasionally, however, genetic elements arise that are able to gain a transmission …

Sleep is an essential behavioral state. It is induced by conserved sleep-active neurons that
express GABA. However, little is known about how sleep neuron function is determined and …

Wounding and infection trigger a protective innate immune response that includes the
production of antimicrobial peptides in the affected tissue as well as increased sleep. Little is …

Sleep is ancient and fulfills higher brain functions as well as basic vital processes. Little is
known about how sleep emerged in evolution and what essential functions it was selected …

Polarization of the C. elegans zygote is initiated by ECT-2-dependent cortical flows, which
mobilize the anterior PAR proteins (PAR-3, PAR-6 and PKC-3) away from the future …