Androgens, which are mediated via the androgen receptor (AR), play important roles in
normal follicular development and female fertility. However, just like a double-edged sword …

The nature and functions of the chemical signals involved in the acquisition of competence
to resume meiosis, and the maintenance of meiotic arrest in antral follicles are the subjects …

During early antral stages of follicular development, granulosa cells are constantly exposed
to a high local concentration of androgen. C 19 steroids biosynthesized in LH-stimulated …

Although chronic hyperandrogenism suppresses antral follicular development, a
phenomenon often observed in polycystic ovarian syndrome (PCOS), whether and how …

Forskolin induced biphasic responses of cumulus progesterone secretion (determined by
RIA) and cumulus mass expansion, with maximal increases occurring at 6· 25 μ m, and …

The present study was undertaken to examine effects of various combinations of epidermal
growth factor (EGF), transforming growth factor‐b̃1 (TGF‐b̃1), follicle‐stimulating hormone …

We have reported that in vitro treatment with follicle-stimulating hormone (FSH) delays by
about 3 h spontaneous meiotic resumption in cumulus cell-enclosed mouse oocytes. In the …

The purpose of this study was to determine if the addition of steroid hormones into the
culture medium could influence the in vitro maturation of pig oocytes. The cumulus–oocyte …

Forskolin (0–100 μ m), a reversible stimulator of the catalytic subunit of adenylate cyclase,
induced dose—response increases in the% germinal vesicle (GV)(ID 50= 2· 68 μ m, where …

The mammalian oocyte is normally arrested in the dictyate stage of the first meiotic division
and resumes meiosis in vivo in response to the appropriate hormonal signals [Ayalon et al …