Fabrication of a shell-core fixed-dose combination tablet using fused deposition modeling 3D printing

A Alzahrani, S Narala, AAA Youssef… - European Journal of …, 2022 - Elsevier
Fixed-dose combinations (FDCs) achieve optimal goals for treatment with minimal side
effects, decreased administration of large number of tablets, thus, greater convenience, and …

Amlodipine/Atorvastatin: a review of its use in the treatment of hypertension and dyslipidaemia and the prevention of cardiovascular disease

MP Curran - Drugs, 2010 - Springer
Amlodipine/atorvastatin (Caduet®) is a single-tablet, fixed-dose combination of the
dihydropyridine calcium channel antagonist amlodipine and the HMG-CoA reductase …

Three different spectrophotometric methods manipulating ratio spectra for determination of binary mixture of Amlodipine and Atorvastatin

HW Darwish, SA Hassan, MY Salem… - Spectrochimica Acta Part …, 2011 - Elsevier
Three simple, specific, accurate and precise spectrophotometric methods manipulating ratio
spectra are developed for the simultaneous determination of Amlodipine besylate (AM) and …

Three different methods for determination of binary mixture of amlodipine and atorvastatin using dual wavelength spectrophotometry

HW Darwish, SA Hassan, MY Salem… - Spectrochimica Acta Part …, 2013 - Elsevier
Three simple, specific, accurate and precise spectrophotometric methods depending on the
proper selection of two wavelengths are developed for the simultaneous determination of …

Combining antihypertensive and antihyperlipidemic agents–optimizing cardiovascular risk factor management

J Zamorano, J Edwards - Integrated blood pressure control, 2011 - Taylor & Francis
Clinical guidelines now recognize the importance of a multifactorial approach to managing
cardiovascular (CV) risk. This idea was taken a step further with the concept of the Polypill™ …

[HTML][HTML] Application of an LC–MS/MS method for the analysis of amlodipine, valsartan and hydrochlorothiazide in polypill for a bioequivalence study

JV Shah, JM Parekh, PA Shah, PV Shah… - Journal of …, 2017 - Elsevier
A sensitive and selective method has been proposed for the simultaneous determination of
amlodipine (AML), valsartan (VAL) and hydrochlorothiazide (HCTZ) in human plasma by …

Simultaneous determination of atorvastatin, amlodipine, ramipril and benazepril in human plasma by LC‐MS/MS and its application to a human pharmacokinetic study

NR Pilli, JK Inamadugu, R Mullangi… - Biomedical …, 2011 - Wiley Online Library
A rapid, simple, sensitive and specific LC‐MS/MS method has been developed and
validated for the simultaneous estimation of atorvastatin (ATO), amlodipine (AML), ramipril …

Proactive multiple cardiovascular risk factor management compared with usual care in patients with hypertension and additional risk factors: the CRUCIAL trial

J Zamorano, S Erdine, A Pavia, JH Kim… - … medical research and …, 2011 - Taylor & Francis
Objective: To investigate whether a proactive multifactorial risk factor intervention strategy
using single-pill amlodipine/atorvastatin (5/10, 10/10 mg) in addition to other …

Pharmacokinetics and bioequivalence evaluation of two formulations of 10-mg amlodipine besylate: an open-label, single-dose, randomized, two-way crossover study …

Y Liu, J Jia, G Liu, S Li, C Lu, Y Liu, C Yu - Clinical therapeutics, 2009 - Elsevier
Background: Amlodipine is a third-generation dihydropyridine calcium antagonist for the
treatment of angina and hypertension. The relative bioavailability of a newly developed …

Simple spectrophotometric methods for the determination of amlodipine and atorvastatin in bulk and tablets

IO Abu Reid, HM Farid, SO Eltayeb - Future Journal of Pharmaceutical …, 2021 - Springer
Background Simultaneous spectrophotometric determination of samples containing more
than one analyte presents analytical challenge; the choice of an analytical procedure is …