Background and Objectives. Human beings have used natural products as one of the
pharmaceutical sources to improve human health for thousands of years. Phytochemical …

Drug-induced nephrotoxicity (DIN) is a major cause of kidney damage and is associated
with high mortality and morbidity, which limits the clinical use of certain therapeutic or …

Hepatotoxicity is one of the major side effects of methotrexate (MTX), which restricts the
clinical use of this drug. Berberine (BBR) is a natural compound with multiple …

Cyclophosphamide (CP) is widely used in treatment of different cancers. Nephrotoxicity is
one of the dose‐limiting side effects of CP. This study was carried out to investigate the effect …

Background The aim of this study was to investigate the effect of ellagic acid (EA) on arsenic-
induced renal and hepatic toxicity in rats. Methods A total number of 35 male Wistar rats …

The major side effect of gentamicin (GEN) is nephrotoxicity which in turn restricts the clinical
use of this drug. In this study, the effect of gallic acid (GA) on gentamicin-induced …

The kidney is the organ most vulnerable to nephrotoxic drugs such as gentamicin.
Nephrotoxicity is a rapid deterioration of kidney function due to various factors. Gentamicin …

Arsenic as a one of the most important toxic metals could induce hepatotoxicity. Previous
reports revealed the significance of oxidative stress in promoting of arsenic-induced liver …

Materials and Methods: The mice received a single IP injection of Cis (20 mg/kg) on the first
day of the experiment. Suma treatment (0.1 and 0.3 mg/kg/day, IP) was started on day 1 and …

Berberine (BBR), an isoquinoline alkaloid, has been reported to be an antioxidant agent.
This study was conducted to investigate the effect of BBR against nephrotoxicity induced by …