RNAi therapeutics have been growing. Patisiran and givosiran, two siRNA-based drugs,
were approved by the Food and Drug Administration in 2018 and 2019, respectively …

Chemokines, which have chemotactic abilities, are comprised of a family of small cytokines
with 8-10 kilodaltons. Chemokines work in immune cells by trafficking and regulating cell …

The CXC chemokine receptor 4 (CXCR4) in endothelial cells (ECs) and vascular smooth
muscle cells (VSMCs) is crucial for vascular integrity. The atheroprotective functions of …

Toll-like receptors (TLRs) in innate immune cells are the prime cellular sensors for microbial
components. TLR activation leads to the production of proinflammatory mediators and thus …

MicroRNAs (miRNAs) regulate cell physiology by altering protein expression, but the biology
of platelet miRNAs is largely unexplored. We tested whether platelet miRNA levels were …

Asymmetrical cell division (ACD) maintains the proper number of stem cells to ensure self-
renewal. In cancer cells, the deregulation of ACD disrupts the homeostasis of the stem cell …

Background Altered patterns of gene expression mediate the effects of particulate matter
(PM) on human health, but mechanisms through which PM modifies gene expression are …

Breast cancer metastasis suppressor 1 (BRMS1) is a predominantly nuclear protein that
differentially regulates expression of multiple genes, leading to suppression of metastasis …

Germ‐line mutations in the BRCA1 gene strongly predispose women to breast cancer
(lifetime risk up to 80%). Furthermore, the BRCA1 protein is absent or present at very low …

Activation of the T cell–mediated immune response has been associated with changes in
the expression of specific microRNAs (miRNAs). However, the role of miRNAs in the …