STING signaling in the brain: Molecular threats, signaling activities, and therapeutic challenges
Stimulator of interferon genes (STING) is an innate immune signaling protein critical to
infections, autoimmunity, and cancer. STING signaling is also emerging as an exciting and …
infections, autoimmunity, and cancer. STING signaling is also emerging as an exciting and …
Transcendent Aspects of Proton Channels
TE DeCoursey - Annual Review of Physiology, 2024 - annualreviews.org
A handful of biological proton-selective ion channels exist. Some open at positive or
negative membrane potentials, others open at low or high pH, and some are light activated …
negative membrane potentials, others open at low or high pH, and some are light activated …
A conserved ion channel function of STING mediates noncanonical autophagy and cell death
The cGAS/STING pathway triggers inflammation upon diverse cellular stresses such as
infection, cellular damage, aging, and diseases. STING also triggers noncanonical …
infection, cellular damage, aging, and diseases. STING also triggers noncanonical …
Second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP): the cell autonomous and non-autonomous roles in cancer progression
X Ma, M Chen, L Meng - Acta Pharmacologica Sinica, 2024 - nature.com
Cytosolic double-stranded DNA (dsDNA) is frequently accumulated in cancer cells due to
chromosomal instability or exogenous stimulation. Cyclic GMP-AMP synthase (cGAS) acts …
chromosomal instability or exogenous stimulation. Cyclic GMP-AMP synthase (cGAS) acts …
A new road to STING activation
A Sulpizio, LL Lairson - Nature Chemical Biology, 2024 - nature.com
Activation of STING-dependent signal transduction results in adaptive immune responses
that promote antitumor immunity. A recent study has identified a small-molecule STING …
that promote antitumor immunity. A recent study has identified a small-molecule STING …
[HTML][HTML] Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection
Modified vaccinia Ankara (MVA) virus does not replicate in human cells and is the vaccine
deployed to curb the current outbreak of mpox. Here, we conduct a multiplexed proteomic …
deployed to curb the current outbreak of mpox. Here, we conduct a multiplexed proteomic …
ER: a critical hub for STING signaling regulation
Abstract The Stimulator of Interferon Genes (STING) has a crucial role in mediating the
immune response against cytosolic double-stranded DNA (dsDNA) and its activation is …
immune response against cytosolic double-stranded DNA (dsDNA) and its activation is …
cGAS-like receptors: back to the future
F Humphries - Trends in Immunology, 2023 - cell.com
Recent studies have characterized ancient forms of cyclic GMP-AMP (cGAMP) synthase
(cGAS)-like receptors (cGLRs) in bacterial and Drosophila immunity. Using bioinformatics …
(cGAS)-like receptors (cGLRs) in bacterial and Drosophila immunity. Using bioinformatics …
The ion channels of endomembranes
M Hu, X Feng, Q Liu, S Liu, F Huang… - Physiological …, 2024 - journals.physiology.org
The endomembrane system consists of organellar membranes in the biosynthetic pathway
[endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles] as well as those in the …
[endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles] as well as those in the …
Applications of cryo-EM in drug development for STING
STING is a critical adaptor protein in the cGAS-mediated DNA-sensing innate immune
pathway. Binding of the second messenger cGAMP generated by cGAS to STING induces …
pathway. Binding of the second messenger cGAMP generated by cGAS to STING induces …