It is widely accepted that hypoperfusion and changes in capillary morphology are involved in
the etiopathogenesis of Alzheimer's disease (AD). This is difficult to reconcile with the …

Physics has delivered extraordinary developments in almost every facet of modern life. From
the humble thermometer and stethoscope to X‐Ray, CT, MRI, ultrasound, PET and …

Normal brain function depends critically on moment-to-moment regulation of oxygen supply
by the bloodstream to meet changing metabolic needs. Neurovascular coupling, a range of …

Plastic changes in motor cortex capillary structure and function were examined in three
separate experiments in adult rats following prolonged exercise. The first two experiments …

One of the major limitations in the current set of techniques available to neuroscientists is a
dearth of methods for imaging individual cells deep within the brains of live animals. To …

The effect of the basal cerebral blood flow (CBF) on both the magnitude and dynamics of the
functional hemodynamic response in humans has not been fully investigated. Thus, the …

The pathophysiology of cerebral ischemia is traditionally understood in relation to reductions
in cerebral blood flow (CBF). However, a recent reanalysis of the flow-diffusion equation …

It is widely assumed in fMRI that the relationship between cerebral blood flow (CBF) and
volume (CBV) changes observed during end-tidal CO2 (PETCO2) perturbations is …

The blood brain barrier (BBB) is the main barrier that separates the blood from the brain.
Because of the BBB, the drug concentration-time profile in the brain may be substantially …

We recently extended the classic flow–diffusion equation, which relates blood flow to tissue
oxygenation, to take capillary transit time heterogeneity (CTH) into account. Realizing that …