[HTML][HTML] The potential role of m6A RNA methylation in the aging process and aging-associated diseases
J Sun, B Cheng, Y Su, M Li, S Ma, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
N6-methyladenosine (m6A) is the most common and conserved internal eukaryotic mRNA
modification. m6A modification is a dynamic and reversible post-transcriptional regulatory …
modification. m6A modification is a dynamic and reversible post-transcriptional regulatory …
Chemical Inhibitors Targeting the Oncogenic m6A Modifying Proteins
Y Huang, W Xia, Z Dong, CG Yang - Accounts of Chemical …, 2023 - ACS Publications
Conspectus Epigenetics is brought to RNA, introducing a new dimension to gene
expression regulation. Among numerous RNA modifications, N 6-methyladenosine (m6A) is …
expression regulation. Among numerous RNA modifications, N 6-methyladenosine (m6A) is …
Cross‐Talk between Oxidative Stress and m6A RNA Methylation in Cancer
B Yang, Q Chen - Oxidative Medicine and Cellular Longevity, 2021 - Wiley Online Library
Oxidative stress is a state of imbalance between oxidation and antioxidation. Excessive ROS
levels are an important factor in tumor development. Damage stimulation and excessive …
levels are an important factor in tumor development. Damage stimulation and excessive …
[HTML][HTML] The role of m6A RNA methylation in cancer: implication for nature products anti-cancer research
N Song, K Cui, K Zhang, J Yang, J Liu, Z Miao… - Frontiers in …, 2022 - frontiersin.org
N6-methyladenosine (m6A) RNA methylation is identified as the most common, abundant
and reversible RNA epigenetic modification in messenger RNA (mRNA) and non-coding …
and reversible RNA epigenetic modification in messenger RNA (mRNA) and non-coding …
The RNA m6A Reader YTHDF1 Is Required for Acute Myeloid Leukemia Progression
YG Hong, Z Yang, Y Chen, T Liu, Y Zheng, C Zhou… - Cancer research, 2023 - AACR
Abstract N6-methyladenosine (m6A), the most abundant modification in mRNAs, has been
defined as a crucial modulator in the progression of acute myelogenous leukemia (AML) …
defined as a crucial modulator in the progression of acute myelogenous leukemia (AML) …
[HTML][HTML] RNA m6A demethylase ALKBH5 protects against pancreatic ductal adenocarcinoma via targeting regulators of iron metabolism
R Huang, L Yang, Z Zhang, X Liu, Y Fei… - Frontiers in cell and …, 2021 - frontiersin.org
Although RNA m6A regulators have been implicated in the tumorigenesis of several different
types of tumors, including pancreatic cancer, their clinical relevance and intrinsic regulatory …
types of tumors, including pancreatic cancer, their clinical relevance and intrinsic regulatory …
[HTML][HTML] RNA demethylase ALKBH5 promotes tumorigenesis in multiple myeloma via TRAF1-mediated activation of NF-κB and MAPK signaling pathways
J Qu, Y Hou, Q Chen, J Chen, Y Li, E Zhang, H Gu… - Oncogene, 2022 - nature.com
Abstract N6-methyladenosine (m6A), an internal modification in mRNA, plays a critical role
in regulating gene expression. Dysregulation of m6A modifiers promotes oncogenesis …
in regulating gene expression. Dysregulation of m6A modifiers promotes oncogenesis …
m6A-express: uncovering complex and condition-specific m6A regulation of gene expression
T Zhang, SW Zhang, SY Zhang, SJ Gao… - Nucleic acids …, 2021 - academic.oup.com
Abstract N6-methyladenosine (m6A) is the most abundant form of mRNA modification and
controls many aspects of RNA metabolism including gene expression. However, the …
controls many aspects of RNA metabolism including gene expression. However, the …
[PDF][PDF] N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation
Summary N 6-Methyladenosine (m 6 A) on mRNAs mediates different biological processes
and its dysregulation contributes to tumorigenesis. How m 6 A dictates its diverse molecular …
and its dysregulation contributes to tumorigenesis. How m 6 A dictates its diverse molecular …
METTL3 mediates osteoblast apoptosis by regulating endoplasmic reticulum stress during LPS-induced inflammation
Y Kong, Y Zhang, Y Cai, D Li, B Yi, Q Xu - Cellular Signalling, 2022 - Elsevier
Osteoblast apoptosis is a prominent factor for disrupting skeletal homeostasis in multiple
inflammatory bone diseases. METTL3, a key methyltransferase that catalyzes the N6 …
inflammatory bone diseases. METTL3, a key methyltransferase that catalyzes the N6 …