Abstract N6-methyladenosine (m6A), an internal modification in mRNA, plays a critical role
in regulating gene expression. Dysregulation of m6A modifiers promotes oncogenesis …

Summary N 6-Methyladenosine (m 6 A) on mRNAs mediates different biological processes
and its dysregulation contributes to tumorigenesis. How m 6 A dictates its diverse molecular …

Although RNA m6A regulators have been implicated in the tumorigenesis of several different
types of tumors, including pancreatic cancer, their clinical relevance and intrinsic regulatory …

Abstract AlkB homolog 5 (ALKBH5) is an RNA m 6 A demethylase involved in the regulation
of genes transcription, translation and metabolism and has been considered as a promising …

SF3B1 is the most mutated splicing factor (SF) in myelodysplastic syndromes (MDSs), which
are clonal hematopoietic disorders with variable risk of leukemic transformation. Although …

Acute myeloid leukemia (AML) is the most common hematopoietic malignancies, and
chemotherapy resistance is one of the main causes of relapse. Because of lower survival …

Osteoblast apoptosis is a prominent factor for disrupting skeletal homeostasis in multiple
inflammatory bone diseases. METTL3, a key methyltransferase that catalyzes the N6 …

Background ALKBH5 is aberrantly activated and exerts critical roles in facilitating the
development of glioblastoma. However, the underlying activation mechanism by which …

Stem cells regulate their self-renewal and differentiation fate outcomes through both
symmetric and asymmetric divisions. m 6 A RNA methylation controls symmetric commitment …

Abstract N6-methyladenosine (m6A) is the most abundant form of mRNA modification and
controls many aspects of RNA metabolism including gene expression. However, the …