Mitochondrial dysfunction: roles in skeletal muscle atrophy

X Chen, Y Ji, R Liu, X Zhu, K Wang, X Yang… - Journal of Translational …, 2023 - Springer
Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle
health, and damage to mitochondria can lead to a series of pathophysiological changes …

Mitochondrial dysfunction and skeletal muscle atrophy: Causes, mechanisms, and treatment strategies

GB Kubat, E Bouhamida, O Ulger, I Turkel, G Pedriali… - Mitochondrion, 2023 - Elsevier
Skeletal muscle, which accounts for approximately 40% of total body weight, is one of the
most dynamic and plastic tissues in the human body and plays a vital role in movement …

[HTML][HTML] Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress

LJ Delfinis, CA Bellissimo, S Gandhi, SN DiBenedetto… - JCI insight, 2022 - ncbi.nlm.nih.gov
Muscle weakness and wasting are defining features of cancer-induced cachexia.
Mitochondrial stress occurs before atrophy in certain muscles, but the possibility of …

Adverse effects of systemic cancer therapy on skeletal muscle: myotoxicity comes out of the closet

P Klassen, DL Schiessel… - Current Opinion in Clinical …, 2023 - journals.lww.com
The adverse side effect of cancer therapy on skeletal muscle has been largely ignored in the
development of cancer therapeutics. Given the extent to which loss of muscle mass and …

Role of p53 in cisplatin-induced myotube atrophy

C Matsumoto, H Sekine, N Zhang, S Mogami… - International Journal of …, 2023 - mdpi.com
Chemotherapy-induced sarcopenia is an unfavorable prognostic factor implicated in the
development of postoperative complications and reduces the quality of life of patients with …

Age-related and cancer-related sarcopenia: is there a difference?

F Bozzetti - Current Opinion in Clinical Nutrition & Metabolic Care, 2024 - journals.lww.com
Purpose The aim of this review is the attempt to differentiating the pathophysiologic and
clinical features of the aging-related sarcopenia from cancer-related sarcopenia. In fact …

[HTML][HTML] Kuanoniamine C Suppresses Adipogenesis and White Adipose Tissue Expansion by Modulating Mitochondrial Function

S Oki, S Kageyama, K Machihara… - Biological and …, 2023 - jstage.jst.go.jp
Obesity is characterized by the excessive accumulation of fat to adipose tissue, which is
related to abnormal increasing white adipose tissue (WAT) in the body, and it upregulates …