Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated
with high mortality rates. The primary causes of AKI include ischemia, hypoxia or …

Delayed graft function is a form of acute renal failure resulting in post-transplantation
oliguria, increased allograft immunogenicity and risk of acute rejection episodes, and …

Tissue injury initiates an inflammatory response through the actions of immunostimulatory
molecules referred to as damage-associated molecular patterns (DAMPs). DAMPs …

Understanding the mechanisms of nephron repair is critical for the design of new therapeutic
approaches to treat kidney disease. The kidney can repair after even a severe insult, but …

Regenerative medicine represents a critical clinical goal for patients with ESRD, but the
identification of renal adult multipotent progenitor cells has remained elusive. It is …

The incidence of chronic kidney diseases is increasing worldwide, and these conditions are
emerging as a major public health problem. While genetic factors contribute to susceptibility …

Transforming growth factor (TGF)-βs and their family members, including bone
morphogenetic proteins (BMPs), Nodal and activins, have been implicated in the …

Many adult organs contain stem cells, which are pluripotent and are involved in organ
maintenance and repair after injury. In situ, these cells often have a low cycling rate and …

Chronic kidney disease (CKD) will become the fifth global cause of death by 2040, thus
emphasizing the need to better understand the molecular mechanisms of damage and …

The kidney has a tremendous capacity to regenerate following injury, but factors that govern
this response are still largely unknown. We isolated cells from mouse kidneys with high …