Background Simplistic two-dimensional (2D) in vitro assays have long been the standard for
studying the metastatic abilities of cancer cells. However, tri-dimensional (3D) organotypic …

The origin of metastases is a topic that has sparked controversy. Despite recent
advancements, metastatic disease continues to pose challenges. The first admitted model of …

Brain metastasis is the main cause of treatment failure and melanoma-related death.
Inadequate concentrations of therapeutic drugs in the brain due to the blood-brain barrier …

In the advanced phase, there is a high risk of chondrosarcoma cells metastasizing to various
organs. The conventional treatment, surgery, has shown low efficacy in the metastasis stage …

Prolactin (PRL) is a polypeptide hormone synthesized in the lactotrophs of the
adenohypophysis and in extrahypophyseal glands (such as the prostate and breasts) where …

Background/Aim: A disintegrin and metalloprotease (ADAM) 12 expression has been found
up-regulated in various cancer types. The aim of the study was to evaluate whether ADAM12 …

Tumor metastasis, the spread of tumor cells from their place of origin to surrounding tissues
and then distant organs through vasculatures, is the major cause of cancer mortality. Despite …

Abstract Background/Aim: Engulfment and cell motility 1 (ELMO1) plays a crucial role in the
process of migration, chemotaxis, and metastasis of tumor cells. ELMO1 has been …

Due to its propensity to metastasize, cancer remains one of the leading causes of death
worldwide. Thanks in part to their intrinsic low cytotoxicity, the effects of the flavonoid family …

Simple Summary A possible way to inhibit tumor cells migration could be strengthening
adhesion between tumor and stromal cells in primary solid tumors. Expanding on our …