Secondary bile acids (BAs) and short chain fatty acids (SCFAs), two major types of bacterial
metabolites in the colon, cause opposing effects on colonic inflammation at chronically high …

G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling
receptors known to play a crucial role in various physiological functions, including tumor …

Neutrophils act as the first line of defense against invading pathogens. Although traditionally
considered in context of their antimicrobial effector functions, the importance of tumor …

Renin-angiotensin system (RAS) inhibitors (RASi)—widely prescribed for the treatment of
cardiovascular diseases—have considerable potential in oncology. The RAS plays a crucial …

Chronic inflammation can drive tumor development. Here, we have identified microRNA-
146a (miR-146a) as a major negative regulator of colonic inflammation and associated …

Colorectal cancer (CRC) is one of the most frequent causes of cancer death worldwide and
is associated with adoption of a diet high in animal protein and saturated fat. Saturated fat …

The natural history of a tumor includes phases of 'in situ'growth, invasion, extravasation and
metastasis. During these phases, tumor cells interact with their microenvironment and are …

Neutrophils are myeloid cells that constitute 50–70% of all white blood cells in the human
circulation. Traditionally, neutrophils are viewed as the first line of defense against infections …

G protein‐coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a
diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled …

Due to the aging of the populations of developed countries and a common occurrence of risk
factors, it is increasingly probable that a patient may have both cancer and cardiovascular …