[HTML][HTML] Secondary bile acids and short chain fatty acids in the colon: a focus on colonic microbiome, cell proliferation, inflammation, and cancer
H Zeng, S Umar, B Rust, D Lazarova… - International journal of …, 2019 - mdpi.com
Secondary bile acids (BAs) and short chain fatty acids (SCFAs), two major types of bacterial
metabolites in the colon, cause opposing effects on colonic inflammation at chronically high …
metabolites in the colon, cause opposing effects on colonic inflammation at chronically high …
[HTML][HTML] An insight into GPCR and G-proteins as cancer drivers
PK Chaudhary, S Kim - Cells, 2021 - mdpi.com
G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling
receptors known to play a crucial role in various physiological functions, including tumor …
receptors known to play a crucial role in various physiological functions, including tumor …
[HTML][HTML] An Attempt to Polarize Human Neutrophils Toward N1 and N2 Phenotypes in vitro
M Ohms, S Möller, T Laskay - Frontiers in immunology, 2020 - frontiersin.org
Neutrophils act as the first line of defense against invading pathogens. Although traditionally
considered in context of their antimicrobial effector functions, the importance of tumor …
considered in context of their antimicrobial effector functions, the importance of tumor …
Targeting the renin-angiotensin system to improve cancer treatment: Implications for immunotherapy
Renin-angiotensin system (RAS) inhibitors (RASi)—widely prescribed for the treatment of
cardiovascular diseases—have considerable potential in oncology. The RAS plays a crucial …
cardiovascular diseases—have considerable potential in oncology. The RAS plays a crucial …
[HTML][HTML] MicroRNA-146a limits tumorigenic inflammation in colorectal cancer
LP Garo, AK Ajay, M Fujiwara, G Gabriely… - Nature …, 2021 - nature.com
Chronic inflammation can drive tumor development. Here, we have identified microRNA-
146a (miR-146a) as a major negative regulator of colonic inflammation and associated …
146a (miR-146a) as a major negative regulator of colonic inflammation and associated …
Taurocholic acid metabolism by gut microbes and colon cancer
Colorectal cancer (CRC) is one of the most frequent causes of cancer death worldwide and
is associated with adoption of a diet high in animal protein and saturated fat. Saturated fat …
is associated with adoption of a diet high in animal protein and saturated fat. Saturated fat …
Immune infiltration in human tumors: a prognostic factor that should not be ignored
J Galon, MC Dieu-Nosjean, E Tartour… - Oncogene, 2010 - nature.com
The natural history of a tumor includes phases of 'in situ'growth, invasion, extravasation and
metastasis. During these phases, tumor cells interact with their microenvironment and are …
metastasis. During these phases, tumor cells interact with their microenvironment and are …
The multifaceted roles neutrophils play in the tumor microenvironment
Neutrophils are myeloid cells that constitute 50–70% of all white blood cells in the human
circulation. Traditionally, neutrophils are viewed as the first line of defense against infections …
circulation. Traditionally, neutrophils are viewed as the first line of defense against infections …
G Protein‐Coupled receptors and heterotrimeric G proteins as cancer drivers
N Arang, JS Gutkind - FEBS letters, 2020 - Wiley Online Library
G protein‐coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a
diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled …
diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled …
Cardiotoxicity of anticancer drugs: the need for cardio-oncology and cardio-oncological prevention
A Albini, G Pennesi, F Donatelli… - Journal of the …, 2010 - academic.oup.com
Due to the aging of the populations of developed countries and a common occurrence of risk
factors, it is increasingly probable that a patient may have both cancer and cardiovascular …
factors, it is increasingly probable that a patient may have both cancer and cardiovascular …