Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
YAP/TAZ: drivers of tumor growth, metastasis, and resistance to therapy
BJ Thompson - Bioessays, 2020 - Wiley Online Library
The transcriptional co‐activators YAP (or YAP1) and TAZ (or WWTR1) are frequently
activated during the growth and progression of many solid tumors, including lung, colorectal …
activated during the growth and progression of many solid tumors, including lung, colorectal …
[HTML][HTML] Biomaterials to enhance stem cell transplantation
The successful transplantation of stem cells has the potential to transform regenerative
medicine approaches and open promising avenues to repair, replace, and regenerate …
medicine approaches and open promising avenues to repair, replace, and regenerate …
LPA receptor signaling: pharmacology, physiology, and pathophysiology
Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and
nonvertebrate organisms that mediates diverse biological actions and demonstrates …
nonvertebrate organisms that mediates diverse biological actions and demonstrates …
Epidermal growth factor receptor (EGFR) signaling in cancer
N Normanno, A De Luca, C Bianco, L Strizzi… - Gene, 2006 - Elsevier
The epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine
kinases (RTK). These trans-membrane proteins are activated following binding with peptide …
kinases (RTK). These trans-membrane proteins are activated following binding with peptide …
Regulation of cardiac hypertrophy by intracellular signalling pathways
J Heineke, JD Molkentin - Nature reviews Molecular cell biology, 2006 - nature.com
The mammalian heart is a dynamic organ that can grow and change to accommodate
alterations in its workload. During development and in response to physiological stimuli or …
alterations in its workload. During development and in response to physiological stimuli or …
The epidermal growth factor receptor family: biology driving targeted therapeutics
MJ Wieduwilt, MM Moasser - Cellular and molecular life sciences, 2008 - Springer
The epidermal growth factor family of receptor tyrosine kinases (ErbBs) plays essential roles
in regulating cell proliferation, survival, differentiation and migration. The ErbB receptors …
in regulating cell proliferation, survival, differentiation and migration. The ErbB receptors …
Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS
VB Patel, N Clarke, Z Wang, D Fan, N Parajuli… - Journal of molecular and …, 2014 - Elsevier
Angiotensin converting enzyme (ACE) 2 is a key negative regulator of the renin–angiotensin
system where it metabolizes angiotensin (Ang) II into Ang 1–7. We hypothesize that Ang II …
system where it metabolizes angiotensin (Ang) II into Ang 1–7. We hypothesize that Ang II …
Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma
R Bonavia, A Mukasa, Y Narita, DWY Sah… - Genes & …, 2010 - genesdev.cshlp.org
Human solid tumors frequently have pronounced heterogeneity of both neoplastic and
normal cells on the histological, genetic, and gene expression levels. While current efforts …
normal cells on the histological, genetic, and gene expression levels. While current efforts …
GPCRs: Emerging anti-cancer drug targets
AN Gutierrez, PH McDonald - Cellular signalling, 2018 - Elsevier
G protein-coupled receptors (GPCRs) constitute the largest and most diverse protein family
in the human genome with over 800 members identified to date. They play critical roles in …
in the human genome with over 800 members identified to date. They play critical roles in …