Oestrogen-related receptors (ERRs) are orphan nuclear receptors that were initially
investigated in breast cancer because of their structural relationship to oestrogen receptors …

The endothelial cells (ECs) make up the inner lining of blood vessels, acting as a barrier
separating the blood and the tissues in several organs. ECs maintain endothelium integrity …

Proliferating cells need to produce a large amount of energy and, at the same time, need to
maintain a constant supply of biosynthetic precursors of macromolecules that are used as …

A genomic signature designed to assess the activity of the estrogen-related receptor alpha
(ERRα) was used to profile more than 800 breast tumors, revealing a shorter disease-free …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are posing great threats to
global health within this century. Studies have suggested that estrogen and estrogen …

Severe forms of pulmonary arterial hypertension (PAH) are most frequently the
consequence of a lumen-obliterating angiopathy. One pathobiological model is that the …

Low-oxygen tolerance is supported by an adaptive response that includes a coordinate shift
in metabolism and the activation of a transcriptional program that is driven by the hypoxia …

Although ageing impairs cardiovascular health in both men and women, the timeline is
different between the sexes. This is at least partially attributed to the loss of oestrogen in …

Estrogen-signaling pathways are implicated in the development of breast cancer and
prostate cancer. Various studies have focused on additional signaling pathways, mediated …

Osteoporosis develops because of impaired bone formation and/or excessive bone
resorption. Several pharmacological treatment of osteoporosis has been developed; …