Pesticides at brain borders: Impact on the blood-brain barrier, neuroinflammation, and neurological risk trajectories

N Cresto, I Forner-Piquer, A Baig, M Chatterjee… - Chemosphere, 2023 - Elsevier
Pesticides are omnipresent, and they pose significant environmental and health risks.
Translational studies indicate that acute exposure to high pesticide levels is detrimental, and …

Assessing the contribution of the chemical exposome to neurodegenerative disease

S Lefevre-Arbogast, J Chaker, F Mercier… - Nature …, 2024 - nature.com
Over the past few decades, numerous environmental chemicals from solvents to pesticides
have been suggested to be involved in the development and progression of …

[HTML][HTML] Neuroprotective potentials of flavonoids: Experimental studies and mechanisms of action

P Bellavite - Antioxidants, 2023 - mdpi.com
Neurological and neurodegenerative diseases, particularly those related to aging, are on
the rise, but drug therapies are rarely curative. Functional disorders and the organic …

[HTML][HTML] Kolaviron abates busulfan-induced episodic memory deficit and testicular dysfunction in rats: the implications for neuroendopathobiological changes during …

MO Oyovwi, B Ben-Azu, TP Edesiri, E Victor… - Biomedicine & …, 2021 - Elsevier
Busulfan is a popular antileukemia chemotherapeutic alkylating agent widely known to
induce variety of serious adverse effects including chemobrain-related cognitive …

Quercetin protects against levetiracetam induced gonadotoxicity in rats

MO Oyovwi, OB Oghenetega, E Victor, FY Faith… - Toxicology, 2023 - Elsevier
The purpose of this study was to determine whether quercetin may counteract the negative
effects of levetiracetam on rat reproductive capabilities by examining its influence on a few …

Kolaviron, a flavonoid‐rich extract ameliorates busulfan‐induced chemo‐brain and testicular damage in male rats through inhibition of oxidative stress, inflammatory …

EP Tesi, B Ben‐Azu, OO Mega, J Mordi… - Journal of food …, 2022 - Wiley Online Library
Previous reports revealed that increased oxidative stress with up‐regulated inflammatory
proteins and apoptotic factors have serious implications in busulfan‐induced chemo‐brain …

[HTML][HTML] Curcumin-resveratrol nano-formulation counteracting hyperammonemia in rats

M Nasr, OAH Ahmed-Farid, RF Ahmed - Metabolic Brain Disease, 2023 - Springer
Malnutrition and low dietary protein intake could be risk factors for developing peripheral
and central hyperammonemia, especially in pediatrics. Both curcumin and resveratrol …

d‐ribose‐ l‐cysteine abrogates testicular maladaptive responses induced by polychlorinated bisphenol intoxication in rats via activation of the mTOR signaling …

OO Mega, TP Edesiri, E Victor… - … of Biochemical and …, 2022 - Wiley Online Library
Male reproductive maladaptive responses are becoming a global health concern and also a
social issue. Polychlorinated biphenyls (PCBs) are a member of halogenated aromatic …

Possible mechanisms involved in the testicular-protective property of quercetin in rats exposed to endosulfan toxicity

OO Mega, BA Benneth, TP Edesiri, RA Rume… - Pesticide Biochemistry …, 2022 - Elsevier
The study investigated the effects of quercetin and putative mechanisms involved against
endosulfan-testicular impairments in rats. Rats were allotted into five treatment groups (n …

Role of melatonin and quercetin as countermeasures to the mitochondrial dysfunction induced by titanium dioxide nanoparticles

N Nalika, M Waseem, P Kaushik, M Salman… - Life Sciences, 2023 - Elsevier
Aim Due to the growing commercialization of titanium dioxide nanoparticles (TNPs), it is
necessary to use these particles in a manner that is safe, healthy and environmental friendly …