Protein aggregation is implicated in multiple diseases, so-called proteinopathies, ranging
from neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease …

Pyruvate kinase (PK) is a key enzyme in glycolysis, the sole source of adenosine
triphosphate, which is essential for all energy-dependent activities of red blood cells …

Osteoarthritis (OA) is the most common joint disorder, and disease-modifying OA drugs
(DMOADs) represent a major need in OA management. Krüppel-like factor 4 (KLF4) is a …

Ex vivo cellular system that accurately replicates sickle cell disease and β-thalassemia
characteristics is a highly sought-after goal in the field of erythroid biology. In this study, we …

Stable, mixed-donor–recipient chimerism after allogeneic hematopoietic stem cell
transplantation (HSCT) for patients with sickle cell disease (SCD) is sufficient for phenotypic …

The occurrence of vaso-occlusive crisis greatly depends on the competition between the
sickling delay time and the transit time of individual sickle cells, ie, red blood cells from sickle …

Sickle cell disease is a missense genetic disorder characterized by the aggregation of deoxy-
HbS into helical fibers that distort erythrocytes into a sickle-like shape. Herein, we …

Since the formation of a DNA duplex plays a vital role in gene expression and regulation
across all kinds of organisms, quantifying the interaction during DNA hybridization is …

2, 3-diphosphoglycerate (DPG) in red blood cells (RBCs) stabilizes deoxyhemoglobin to
promote hemoglobin (Hb) oxygen off-loading and counteract hypoxia. In sickle cell disease …

Sickle cell disease (SCD) is one of the most common and clinically severe inherited
diseases in the world, estimated to affect at least 3 to 6 million people. Greater than 90% of …