Plant-derived natural products for drug discovery: current approaches and prospects

N Nasim, IS Sandeep, S Mohanty - The Nucleus, 2022 - Springer
Nature has abundant source of drugs that need to be identified/purified for use as essential
biologics, either individually or in combination in the modern medical field. These drugs are …

Targeting the PI3K/AKT/mTOR signaling pathway in lung cancer: an update regarding potential drugs and natural products

Iksen, S Pothongsrisit, V Pongrakhananon - Molecules, 2021 - mdpi.com
Lung cancer is one of the most common cancers and has a high mortality rate. Due to its
high incidence, the clinical management of the disease remains a major challenge. Several …

Pharmacokinetics and drug-likeness of antidiabetic flavonoids: Molecular docking and DFT study

M Bitew, T Desalegn, TB Demissie, A Belayneh… - Plos one, 2021 - journals.plos.org
Computer aided toxicity and pharmacokinetic prediction studies attracted the attention of
pharmaceutical industries as an alternative means to predict potential drug candidates. In …

Nanoparticles and nanofiltration for wastewater treatment: From polluted to fresh water

TM Joseph, HE Al-Hazmi, B Śniatała, A Esmaeili… - Environmental …, 2023 - Elsevier
Water pollution poses significant threats to both ecosystems and human health. Mitigating
this issue requires effective treatment of domestic wastewater to convert waste into bio …

Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and …

JC Frisvad, LLH Møller, TO Larsen, R Kumar… - Applied Microbiology …, 2018 - Springer
This review presents an update on the current knowledge of the secondary metabolite
potential of the major fungal species used in industrial biotechnology, ie, Aspergillus niger …

CFM-ID 4.0–a web server for accurate MS-based metabolite identification

F Wang, D Allen, S Tian, E Oler, V Gautam… - Nucleic acids …, 2022 - academic.oup.com
Abstract The CFM-ID 4.0 web server (https://cfmid. wishartlab. com) is an online tool for
predicting, annotating and interpreting tandem mass (MS/MS) spectra of small molecules. It …

Immunomodulatory; anti-inflammatory/antioxidant effects of polyphenols: a comparative review on the parental compounds and their metabolites

M Sobhani, MH Farzaei, S Kiani… - Food Reviews …, 2021 - Taylor & Francis
Polyphenols are a big family of phytochemicals that includes a wide range of natural
substances with various biological activities. Amongst these activities, the …

An overview on natural product drug formulations from conventional medicines to nanomedicines: Past, present and future

AA Elkordy, RR Haj-Ahmad, AS Awaad… - Journal of Drug Delivery …, 2021 - Elsevier
For decades, naturally produced plants have been studied and used in herbalism (herbal
medicines). Despite being natural, these products were not of any interest of any of the …

Naturally-occurring alkaloids of plant origin as potential antimicrobials against antibiotic-resistant infections

B Casciaro, L Mangiardi, F Cappiello, I Romeo… - Molecules, 2020 - mdpi.com
Antibiotic resistance is now considered a worldwide problem that puts public health at risk.
The onset of bacterial strains resistant to conventional antibiotics and the scarcity of new …

[HTML][HTML] Sepsis-mediated renal dysfunction: pathophysiology, biomarkers and role of phytoconstituents in its management

A Balkrishna, S Sinha, A Kumar, V Arya… - Biomedicine & …, 2023 - Elsevier
Sepsis has evolved as an enormous health issue amongst critically ill patients. It is a major
risk factor that results in multiple organ failure and shock. Acute kidney injury (AKI) is one of …