In recent years, the tumour microenvironment (TME) of solid tumours has attracted more and
more attention from researchers, especially those non-tumour components such as immune …

Immune checkpoint blockade (ICB) therapy has achieved breakthroughs in the treatment of
advanced non–small cell lung cancer (NSCLC). Nevertheless, the low response due to …

For individuals with advanced or metastatic non-small cell lung cancer (NSCLC), the primary
treatment is platinum-based doublet chemotherapy. Immune checkpoint inhibitors (ICIs) …

Precision oncology has made significant advances, mainly by targeting actionable mutations
in cancer driver genes. Aiming to expand treatment opportunities, recent studies have begun …

Abstract Background N6-methyladenosine (m6A) RNA methylation plays a critical role in key
genetic events for various cancers; yet, how m6A functions within the tumor …

Abstract Background Histone chaperones (HCs) are crucial for governing genome stability
and gene expression in multiple cancers. However, the functioning of HCs in the tumor …

Background Glutamine (Gln) metabolism has been reported to play an essential role in
cancer. However, a comprehensive analysis of its role in lung adenocarcinoma is still …

Circadian rhythm disruption (CRD) represents a major contributor to tumor proliferation.
Nonetheless, the role of CRD in the clinical prediction of cancer outcomes has not been well …

Cellular senescence is a complex multifactorial biological phenomenon that plays essential
roles in aging, and aging-related diseases. During this process, the senescent cells undergo …

Background Immunotherapy for malignant tumors has made great progress, but many
patients do not benefit from it. The complex intratumoral heterogeneity (ITH) hindered the in …