Immune checkpoint blockades are actively adopted in diverse cancer types including
metastatic melanoma and lung cancer. Despite of durable response in 20–30% of patients …

Background: Increased studies on the basis of bulk RNA-sequencing (RNA-seq) data of
cancer identify numbers of immune-related genes which may play potential regulatory roles …

Chemoimmunotherapy has evolved as a standard treatment for advanced non-small cell
lung cancer (aNSCLC). However, inevitable drug resistance has limited its efficacy …

Osteosarcoma is the most common primary bone malignancy, with a very poor prognosis.
Aberrant glycosylation is close involvement in osteosarcoma. Accordingly, this study aimed …

Purpose The current evaluation methods for tumor infiltrating lymphocytes (TILs), particularly
CD8+ TILs, mainly rely on semiquantitative immunohistochemistry with high variability. We …

Background: Immunotherapy has greatly changed the treatment of advanced non-small cell
lung cancer (NSCLC). Anoikis is a programmed cell death process associated with cancer …

Background: Observational studies have shown that anti-tumor necrosis factor (TNF) therapy
may be beneficial for patients with coronavirus disease 2019 (COVID-19). Nevertheless …

This study constructed a novel gene pair signature based on bulk and single-cell
sequencing samples in relative expression order within the samples. The subsequent …

Background Mitochondrial outer membrane permeabilisation (MOMP) plays a pivotal role in
cellular death and immune activation. A deeper understanding of the impact of tumour …

Background Molecular subtyping is expected to enable precise treatment. However, reliable
subtyping strategies for clinical application remains defective and controversial. Given the …