DNA mismatch repair

MG Marinus - EcoSal Plus, 2012 - Am Soc Microbiol
DNA mismatch repair (MMR) corrects replication errors in newly synthesized DNA. It also
has an antirecombination action on heteroduplexes that contain similar but not identical …

Within-Host Evolution of Bacterial Pathogens in Acute and Chronic Infection

JP Dekker - Annual Review of Pathology: Mechanisms of …, 2024 - annualreviews.org
Bacterial pathogens undergo remarkable adaptive change in response to the selective
forces they encounter during host colonization and infection. Studies performed over the …

Mismatch Repair of DNA Replication Errors Contributes to Microevolution in the Pathogenic Fungus Cryptococcus neoformans

KJ Boyce, Y Wang, S Verma, VPS Shakya, C Xue… - MBio, 2017 - Am Soc Microbiol
The ability to adapt to a changing environment provides a selective advantage to
microorganisms. In the case of many pathogens, a large change in their environment occurs …

[HTML][HTML] Comparative Transcriptomics of H. pylori Strains AM5, SS1 and Their hpyAVIBM Deletion Mutants: Possible Roles of Cytosine Methylation

R Kumar, AK Mukhopadhyay, P Ghosh, DN Rao - 2012 - journals.plos.org
Helicobacter pylori is an important human pathogen and one of the most successful chronic
colonizers of the human body. H. pylori uses diverse mechanisms to modulate its interaction …

The C-terminal domain is sufficient for endonuclease activity of Neisseria gonorrhoeae MutL

V Duppatla, C Bodda, C Urbanke… - Biochemical …, 2009 - portlandpress.com
The mut L gene of Neisseria gonorrhoeae has been cloned and the gene product purified.
We have found that the homodimeric N. gonorrhoeae MutL (NgoL) protein displays an …

[HTML][HTML] Phenotypic and transcriptional profiling in Entamoeba histolytica reveal costs to fitness and adaptive responses associated with metronidazole resistance

GM Penuliar, K Nakada-Tsukui, T Nozaki - Frontiers in microbiology, 2015 - frontiersin.org
Antimicrobial chemotherapy is critical in the fight against infectious diseases caused by
Entamoeba histolytica. Among the drugs available for the treatment of amebiasis …

[HTML][HTML] The C-Terminal Domain of the MutL Homolog from Neisseria gonorrhoeae Forms an Inverted Homodimer

S Namadurai, D Jain, DS Kulkarni, CR Tabib… - PloS one, 2010 - journals.plos.org
The mismatch repair (MMR) pathway serves to maintain the integrity of the genome by
removing mispaired bases from the newly synthesized strand. In E. coli, MutS, MutL and …

[HTML][HTML] Structural insights into DNA repair by RNase T—an exonuclease processing 3′ end of structured DNA in repair pathways

YY Hsiao, WH Fang, CC Lee, YP Chen, HS Yuan - PLoS Biology, 2014 - journals.plos.org
DNA repair mechanisms are essential for preservation of genome integrity. However, it is not
clear how DNA are selected and processed at broken ends by exonucleases during repair …

[图书][B] Neurodegeneration in accelerated aging

M Scheibye-Knudsen - 2015 - content.ugeskriftet.dk
The global elderly population has been progressively increasing throughout the 20th
century and this growth is projected to persist into the late 21st century resulting in 20% of …

Application of DNA methyltransferases in targeted DNA methylation

A Jeltsch, RZ Jurkowska, TP Jurkowski… - Applied microbiology …, 2007 - Springer
DNA methylation is an essential epigenetic modification. In bacteria, it is involved in gene
regulation, DNA repair, and control of cell cycle. In eukaryotes, it acts in concert with other …