Abstract HIV-1 integrase (IN) is a key enzyme in viral replication that catalyzes the covalent
integration of viral cDNA into the host genome. Currently, five HIV-1 IN strand transfer …

Redondoviridae is a newly established family of circular Rep-encoding single-stranded
(CRESS) DNA viruses found in the human ororespiratory tract. Redondoviruses were …

The retroviral protein Integrase (IN) catalyzes concerted integration of viral DNA into host
chromatin to establish a permanent infection in the target cell. We learned a great deal about …

HIV integrase (IN) inserts viral DNA into the host genome and is the target of the strand
transfer inhibitors (STIs), a class of small molecules currently in clinical use. Another potent …

Retroviral DNA integration is mediated by nucleoprotein complexes (intasomes) in which a
pair of viral DNA ends are bridged by a multimer of integrase (IN). Most of the high …

Integration of retroviral DNA into the host genome involves formation of integrase (IN)-DNA
complexes termed intasomes. Here, we report the single-particle cryo-EM structure of the …

The human immunodeficiency virus (HIV) affects millions of people worldwide who rely on
antiretroviral therapy to prevent the acquired immunodeficiency syndrome and halt further …

Integration of retroviral DNA into the host genome involves the formation of integrase (IN)–
DNA complexes termed intasomes. Further characterization of these complexes is needed …