It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …

Diabetes mellitus currently affects over 350 million patients worldwide and is associated with
many deaths from cardiovascular complications. Sodium–glucose co-transporter 2 (SGLT-2) …

P53 up-regulated modulator of apoptosis (PUMA), a pro-apoptotic BCL-2 homology 3 (BH3)-
only member of the BCL-2 family, is a direct transcriptional target of P53 that elicits …

Background Endoplasmic reticulum (ER) stress-dependent apoptosis had been shown to
occur in the hearts of people with diabetes, although the exact mechanisms are unclear …

The present study is designed to determine the effect of LCZ696 on DCM in rats and
investigate the underlying mechanism involved. Diabetes was induced by feeding rats with a …

The endoplasmic reticulum (ER) is an organelle entrusted with lipid synthesis, calcium
homeostasis, protein folding, and maturation. Perturbation of ER‐associated functions …

Diabetic cardiomyopathy is a significant contributor to the morbidity and mortality associated
with diabetes and metabolic syndrome. However, the underlying molecular mechanisms that …

The renin-angiotensin (Ang) system (RAS) is a complex hormonal system present locally in
several tissues such as cardiovascular organs. RAS deregulation through overactivation of …

Diabetes mellitus has reached an epidemic level worldwide. Cardiovascular diseases are
the primary cause of death in diabetic patients, not only because of coronary artery disease …

Extensive research focused on finding effective strategies to prevent or improve recovery
from myocardial ischaemia/reperfusion (I/R) injury. Basic fibroblast growth factor (b FGF) has …